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Nocloprost, a unique prostaglandin E2 analog with local gastroprotective and ulcer-healing activity.
Eur J Pharmacol
April 1991
Institute of Physiology, Academy of Medicine, Kraków, Poland.
Article Synopsis
- Nocloprost, a prostaglandin E2 (PGE2) analog, was tested for its ability to protect against gastric lesions and promote ulcer healing in rats.
- It effectively prevented gastric damage from various stressors and was more effective when combined with stomach acid, lasting about 8 hours and outperforming another similar compound, dmPGE.
- Unlike dmPGE, nocloprost accelerated the healing of chronic gastric ulcers and enhanced mucosal growth, showing its strong local cytoprotective effects.
Nocloprost, a unique PGE2 analog, with local gastroprotective and ulcer healing activity.
Adv Prostaglandin Thromboxane Leukot Res
March 1991
Institute of Physiology, Academy of Medicine, Krakow.
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