The timing of the retinal input to the lateral geniculate nucleus is highly modified in lagged cells. Evidence is reviewed for how the responses of these cells are generated, how their structure and function differs from their nonlagged neighbors, and what their projections to cortex might do.
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http://dx.doi.org/10.1159/000111564 | DOI Listing |
Elife
January 2025
CNRS UMR168, Institut Curie, Université PSL, Sorbonne Université, Paris, France.
Live-cell microscopy routinely provides massive amounts of time-lapse images of complex cellular systems under various physiological or therapeutic conditions. However, this wealth of data remains difficult to interpret in terms of causal effects. Here, we describe CausalXtract, a flexible computational pipeline that discovers causal and possibly time-lagged effects from morphodynamic features and cell-cell interactions in live-cell imaging data.
View Article and Find Full Text PDFPLoS Genet
January 2025
Department of Animal Sciences, The Ohio State University, Columbus, Ohio, United States of America.
Genomic imprinting is an epigenetic process that results in parent-of-origin effects on mammalian development and growth. Research on genomic imprinting in domesticated animals has lagged due to a primary focus on orthologs of mouse and human imprinted genes. This emphasis has limited the discovery of imprinted genes specific to livestock.
View Article and Find Full Text PDFJ Phys Chem Lett
January 2025
College of Chemistry and Materials Science, Hebei University, Baoding 071002, P. R. China.
The photoelectric conversion efficiency (PCE) of perovskites remains beneath the Shockley-Queisser limit, despite its significant potential for solar cell applications. The present focus is on investigating potential multicomponent perovskite candidates, particularly on the application of machine learning to expedite band gap screening. To efficiently identify high-performance perovskites, we utilized a data set of 1346 hybrid organic-inorganic perovskites and employed 11 machine learning models, including decision trees, convolutional neural networks (CNNs), and graph neural networks (GNNs).
View Article and Find Full Text PDFCell Biol Toxicol
January 2025
Lab. Genetics and Molecular Bases of Complex Diseases, Health Research Institute of Hospital Clínico San Carlos (IdISSC), 28040, Madrid, Spain.
The underlying mechanisms explaining the differential course of SARS-CoV-2 infection and the potential clinical consequences after COVID-19 resolution have not been fully elucidated. As a dysregulated mitochondrial activity could impair the immune response, we explored long-lasting changes in mitochondrial functionality, circulating cytokine levels, and metabolomic profiles of infected individuals after symptoms resolution, to evaluate whether a complete recovery could be achieved. Results of this pilot study evidenced that different parameters of aerobic respiration in lymphocytes of individuals recuperated from a severe course lagged behind those shown upon mild COVID-19 recovery, in basal conditions and after simulated reinfection, and they also showed altered glycolytic capacity.
View Article and Find Full Text PDFNat Commun
January 2025
Regeneron Pharmaceuticals, Inc., Tarrytown, NY, 10591, USA.
The T-cell receptor (TCR)/CD3 complex plays an essential role in the immune response and is a key player in cancer immunotherapies. There are two classes of TCR/CD3 complexes, defined by their TCR chain usage (αβ or γδ). Recently reported structures have revealed the organization of the αβ TCR/CD3 complex, but similar studies regarding the γδ TCR/CD3 complex have lagged behind.
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