Insulinoma and gastrinoma syndromes from a single intrapancreatic neuroendocrine tumor.

Context: The insulinoma syndrome is marked by fasting hypoglycemia and inappropriate elevations of insulin. The gastrinoma syndrome is characterized by hypergastrinemia, ulcer disease, and/or diarrhea. Rarely, insulinoma and gastrinoma coexist in the same patient simultaneously.

Objective: Our objective was to determine the cause of a patient's hypoglycemic episodes and peptic ulcer disease.

Design And Setting: This is a clinical case report from the Clinical Research Center of the National Institutes of Health.

Patient And Intervention: One patient with hypoglycemic episodes and peptic ulcer disease had a surgical resection of neuroendocrine tumor.

Results: The patient was found to have a single tumor cosecreting both insulin and gastrin. Resection of this single tumor was curative.

Conclusions: A single pancreatic neuroendocrine tumor may lead to the expression of both the hyperinsulinemic and hypergastrinemic syndromes.