Reduced sensitivity of influenza A (H5N1) to oseltamivir.

Emerg Infect Dis

CSIRO Molecular and Health Technologies, Parkville, Victoria, Australia.

Published: September 2007

We tested the neuraminidase drug sensitivity of clade 1 and clade 2 influenza A (H5N1). All viruses demonstrated similar sensitivity to zanamivir, but compared with the 2004 clade 1 viruses, the Cambodian 2005 viruses were 6-fold less sensitive and the Indonesian clade 2 viruses were up to 30-fold less sensitive to oseltamivir.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857286PMC
http://dx.doi.org/10.3201/eid1309.070164DOI Listing

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