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Association of PIK3CA somatic mutations with clinicopathological parameters in breast cancer.
Pol J Pathol
January 2025
Karadeniz Technical University, Faculty of Medicine, Department of Pathology, Trabzon, Turkey.
The enzyme phosphatidylinositide-3-kinase (PI3K) regulates cellular proliferation and apoptosis. Somatic mutations in the PIK3CA gene can accelerate these processes and significantly contribute to the development and progression of breast cancer. This study aimed to ascertain the PIK3CA gene mutations in breast cancer patients and investigate their correlation with certain clinicopathological characteristics.
View Article and Find Full Text PDFBRCA1 is involved in sustaining rapid antler growth possibly via balancing of the p53/endoplasmic reticulum stress signaling pathway.
Biol Direct
January 2025
Institute of Antler Science and Product Technology, Changchun Sci-Tech University, Changchun, Jilin, China.
Background: Regeneration is the preferred approach to restore the structure and function after tissue damage. Rapid proliferation of cells over the site of damage is integral to the process of regeneration. However, even subtle mutations in proliferating cells may cause detrimental effects by eliciting abnormal differentiation.
View Article and Find Full Text PDFBridging animal models and humans: neuroimaging as intermediate phenotypes linking genetic or stress factors to anhedonia.
BMC Med
January 2025
Early Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, 264 Guangzhou Street, Nanjing, China.
Background: Intermediate phenotypes, such as characteristic neuroimaging patterns, offer unique insights into the genetic and stress-related underpinnings of neuropsychiatric disorders like depression. This study aimed to identify neuroimaging intermediate phenotypes associated with depression, bridging etiological factors to behavioral manifestations and connecting insights from animal models to diverse clinical populations.
Methods: We analyzed datasets from both rodents and humans.
A qualitative study exploring experiences of treatment in paediatric rheumatology - children's, young people's, parents' and carers' perspectives.
Pediatr Rheumatol Online J
January 2025
School of Pharmacy, Faculty of Medical Sciences, Newcastle University, King George VI Building, Queen Victoria Road, Newcastle-upon-Tyne, NE2 4RU, UK.
Background: There is limited literature in paediatric rheumatology describing holistic lived experiences of medical treatment from perspectives of children and young people (CYP) and their parents or carers (PC). This is important as it could have implications for adherence. This study aimed to explore treatment experiences of CYP and PC in a paediatric rheumatology service.
View Article and Find Full Text PDFLeveraging mRNA technology for antigen based immuno-oncology therapies.
J Immunother Cancer
January 2025
Moderna, Inc, Cambridge, Massachusetts, USA.
The application of messenger RNA (mRNA) technology in antigen-based immuno-oncology therapies represents a significant advancement in cancer treatment. Cancer vaccines are an effective combinatorial partner to sensitize the host immune system to the tumor and boost the efficacy of immune therapies. Selecting suitable tumor antigens is the key step to devising effective vaccinations and amplifying the immune response.
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