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A Case Series of Diagnostic Challenges in Mycosis Fungoides in Resource-poor Settings: Blood Film Examination - A Useful Tool.
Niger Postgrad Med J
October 2024
Department of Medicine, College of Medicine, University of Lagos, Lagos University Teaching Hospital, Lagos, Nigeria.
The prognosis/mortality rate in mycosis fungoides (MF)/cutaneous T-cell lymphomas (CTCL) is alarming in resource-poor countries due to delayed diagnosis in meeting recognised criteria. We highlight the diagnostic accuracy of examining peripheral blood films (PBFs). We reviewed clinically diagnosed MF/CTCL cases in the Dermatology Clinic of Lagos University Teaching Hospital between January and October 2022 and analysed clinical, haematological and histology findings.
View Article and Find Full Text PDFThe inhibition effect of psoralen on prostate cancer PC3 cells via down-regulation of long non-coding RNA ENST00000510619.
Transl Androl Urol
October 2024
Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Hospital, Fuzhou, China.
Background: New medications are needed to improve outcomes of castration-resistant prostate cancer (CRPC). Psoralen has been reported to have anti-cancer properties for various tumors, but there are limited reports about psoralen treatment in prostate cancer (PCa). This study aimed to investigate the effect of psoralen on PC3 cells and to investigate potential underlying mechanisms of action.
View Article and Find Full Text PDFMulti-omics and network pharmacology approaches reveal Gui-Ling-Ji alleviates oligoasthenoteratozoospermia by regulating arachidonic acid pathway.
Phytomedicine
December 2024
Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.; School of Pharmacy, Naval Medical University, Shanghai 200433, China.; School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.; School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.. Electronic address:
Background: Gui-Ling-Ji (GLJ) described in the ancient medical book 'Yunji Qijian' is a traditional Chinese medicine formula used to improve male fertility. It is now available for the treatment of oligoasthenoteratozoospermia (OAT). However, the active ingredients and mechanism of GLJ are not clear.
View Article and Find Full Text PDFNarrowband Ultraviolet B Phototherapy for Generalized Granuloma Annulare: Real-Life Experience and Review of the Literature.
J Cutan Med Surg
October 2024
Dermatology and Venereology Department, Eskisehir Osmangazi University, Eskisehir, Turkey.
Introduction: Generalized granuloma annulare (GA) is an uncommon noninfectious granulomatous dermatitis. Phototherapy is often considered first-line therapy, with more evidence for psoralen ultraviolet A than narrowband ultraviolet B (NB-UVB). We aimed to evaluate the effectiveness and safety of NB-UVB in generalized GA and to review the literature.
View Article and Find Full Text PDFBergapten attenuates sepsis-induced acute lung injury in mice by regulating Th17/Treg balance.
Inhal Toxicol
November 2024
Department of Emergency Medicine, Hanzhong Central Hospital, Hanzhong, China.
Article Synopsis
- Sepsis-induced immune system abnormalities can lead to organ dysfunction, and maintaining the balance between Th17 and Treg cells is crucial for immune health.
- The study used mouse models and various scientific methods to evaluate the effects of bergapten, a natural compound, on inflammation during sepsis.
- Results showed that bergapten reduced lung damage and inflammation by restoring the Th17/Treg balance, suggesting its potential as a treatment for sepsis-related conditions.
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