Development of pyridopyrimidines as potent Akt1/2 inhibitors.

Bioorg Med Chem Lett

Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., PO Box 4, West Point, PA 19486, USA.

Published: February 2008

This communication reports a new synthetic route of pyridopyrimidines to facilitate their structural optimization in a library fashion and describes the development of pyridopyrimidines that have excellent enzymatic and cell potency against Akt1 and Akt2. This series also shows a high level of selectivity over other closely related kinases and significantly improved caspase-3 activity with the more optimized compounds.

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http://dx.doi.org/10.1016/j.bmcl.2008.01.054DOI Listing

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