The cee (conserved edge expressed protein) gene was recently identified in a genome-wide screen to discover genes associated with myotube formation in fast muscle of pufferfish. Comparative genomic analyses indicate that cee arose some 1.6-1.8 billion years ago and is found as a single-copy gene in most eukaryotic genomes examined. The complexity of its structure varies from an intronless gene in yeast and tunicates to nine exons and eight introns in vertebrates. cee is particularly conserved among vertebrates and is located in a syntenic region within tetrapods and between teleosts and invertebrates. Low dN/dS ratios in the cee coding region (0.02-0.09) indicate that the Cee protein is under strong purifying selection. In Atlantic salmon, cee is expressed in the superficial layers of developing organs and tissues. These data, together with functional screens in yeast and Caenorhabditis elegans, indicate that cee has a hitherto uncharacterized role in normal growth and development.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ygeno.2007.10.017 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biodistribution and dosimetry of the PET radioligand [F]CHDI-650 in mice for detection of mutant huntingtin aggregates.
EJNMMI Res
December 2024
μNEURO Research Centre of Excellence, Universiteitsplein 1, University of Antwerp, Antwerp, Belgium.
Background: Huntington's disease (HD) is a rare neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the huntingtin gene which encodes the mutant huntingtin protein (mHTT) that is associated with HD-related neuropathophysiology. Noninvasive visualization of mHTT aggregates in the brain, with positron emission tomography (PET), will allow to reliably evaluate the efficacy of therapeutic interventions in HD. This study aimed to assess the radiation burden of [F]CHDI-650, a novel fluorinated mHTT radioligand, in humans based on both in vivo and ex vivo biodistribution in mice and subsequent determination of dosimetry for dosing in humans.
View Article and Find Full Text PDFSynthesis, Characterization, and BSA Binding Properties of Carboxylated Merocyanine-Based Fluorophores.
ACS Omega
December 2024
Universidade do Extremo Sul Catarinense (UNESC), Av. Universitária, 1105, Criciúma CEP 88806-000, SC, Brazil.
This study describes the synthesis of new carboxylated merocyanine dyes by Knoevenagel condensation between 4-carboxybenzaldehyde and indolium/benzoindolium- and benzothiazolium-based coupling compounds. The condensations were performed in the presence of ammonium acetate, and the products were obtained in good yields after simple purification. These merocyanines exhibit UV-A-to-blue absorption and blue-to-green fluorescence emission, characterized by relatively large Stokes shift values (∼5000 cm).
View Article and Find Full Text PDFMicrofluidic-based fluorescence enhancement of silica-embedded carbon dots for direct detection and quantification of unamplified HCV RNA in clinical samples.
Anal Chim Acta
January 2025
Center of Genomics, Helmy Institute, Zewail City of Science and Technology, Sheikh Zayed Dist, 12588, Giza, Egypt; Pathology and Molecular Genomics Unit of Medical Ain Shams Research Institute (MASRI), Faculty of Medicine, Ain Shams University. Cairo, 11591, Cairo, Egypt; Biochemistry Department, Faculty of Pharmacy, Misr University for Science and Technology, 12566, Giza, Egypt. Electronic address:
Article Synopsis
- Hepatitis C Virus (HCV) is a serious, chronic infection that often shows no symptoms, making early detection crucial for treatment and infection control.
- Current detection methods like PCR are expensive and time-consuming, which limits their use in smaller labs and field settings.
- A new technology using crosslinked Enhanced Emission (CEE) has been developed for detecting HCV RNA with high sensitivity and speed, allowing results in under 20 minutes via a 3D-printed microfluidic chip, achieving impressive sensitivity (96.47%) and specificity (98.79%).
Calcium sources can increase mechanical properties of 3D printed bioactive hybrid bone scaffolds.
RSC Adv
November 2024
Department of Materials, Imperial College London London UK
Inorganic/organic hybrid biomaterials have been developed to obtain synergy of the inorganic and organic co-networks for implant and 3D printed scaffold applications, providing combinations of bioactivity, toughness and controlled biodegradation. SiO-CaO/PTHF/PCL-diCOOH sol-gel hybrids previously showed potential for osteogenesis due to the addition of calcium to the silicate network of the hybrid, using calcium methoxyethoxide (CME) as the calcium source. Here, we investigate other calcium sources to improve mechanical properties and printability of the hybrid inks.
View Article and Find Full Text PDFCoupling coordination and spatial network characteristics of carbon emission efficiency and urban green innovation in the Yellow River Basin, China.
Sci Rep
November 2024
College of Management Science, Chengdu University of Technology, 1 East Third Road, Erxian Bridge, Chenghua District, Chengdu, 610059, Sichuan, P.R. China.
Carbon emission and sustainable development have attracted global attention. Promoting urban green innovation (UGI) in the Yellow River Basin (YRB) will help in lowering the intensity of carbon emissions and improve the safety and sustainability. A SBM-DEA model was constructed to measure carbon emission efficiency (CEE) and the degree of coupling and coordination with UGI was calculated in 73 prefecture-level cities in the YRB.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!