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Citric acid is more effective than sodium thiosulfate in chelating calcium in a dissolution model of calcinosis.
Sci Rep
December 2024
Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester and Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, M13 9PT, UK.
Calcinosis cutis affects 20-40% of patients with systemic sclerosis. This study tests the hypothesis that calcium-chelating polycarboxylic acids can induce calcium dissolution without skin toxicity or irritancy. We compared citric acid (CA) and ethylenediaminetetraacetic acid (EDTA) to sodium thiosulfate (STS) for their ability to chelate calcium in vitro using a pharmaceutical dissolution model of calcinosis (hydroxyapatite (HAp) tablet), prior to evaluation of toxicity and irritancy in 2D in vitro skin models.
View Article and Find Full Text PDFA case of symmetrical subepidermal calcified nodules on the eyelids.
Dermatol Reports
November 2024
Department of Dermatology, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
Hyperphosphatemic Familial Tumoral Calcinosis.
South Med J
December 2024
Department of Dermatology, Mayo Clinic, Jacksonville, Florida.
Hyperphosphatemic familial tumoral calcinosis (HFTC) is a rare, autosomal recessive condition characterized by fibroblast growth factor 23 signaling pathway dysregulation, hyperphosphatemia and ectopic calcifications (which manifest as joint motion limitations), inflammatory bony pain, and disability. Given the rarity and multiorgan involvement of HFTC, a multidisciplinary approach including Dermatology, Ophthalmology, Dentistry, Nephrology, Endocrinology, Rheumatology, and Genetics is necessary for diagnosis and treatment. We present a multidisciplinary diagnostic and treatment approach for a patient with HFTC due to a gene mutation with unique imaging highlighting the extent of calcinosis seen in HFTC.
View Article and Find Full Text PDFIdiopathic calcinosis cutis of scrotum (ICCS): excision with scrotoplasty.
BMJ Case Rep
November 2024
Plastic, Reconstructive and Burns Surgery, All India Institute of Medical Sciences, New Delhi, India
Scrotal calcinosis is an infrequent benign pathological condition characterised by the presence of multiple calcified nodules on the skin of the scrotum. Despite the formulation of several theories, the precise pathogenesis of this condition remains a subject of controversy within the scientific community. The predominant concern associated with scrotal calcinosis is of an aesthetic nature, and histological examination serves as the definitive method for confirmation of the diagnosis.
View Article and Find Full Text PDFA Clinicopathological Study of Scrotal Calcinosis and Literature Review.
Int J Surg Pathol
November 2024
Department of Pathology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Article Synopsis
- The study examined 14 adult men with scrotal calcinosis to understand its clinicopathological features and potential causes, finding that it typically appears as hard nodules on the scrotum.
- The analysis included comparisons with 81 cases of extrascrotal calcinosis and a large group of patients with epidermoid cysts, suggesting that scrotal calcinosis may arise from epidermoid cysts rather than being idiopathic.
- The disease is characterized by calcium deposits in the skin and is generally asymptomatic, with surgical excision being an effective treatment.
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