We present deterministic nonmonotone learning strategies for multilayer perceptrons (MLPs), i.e., deterministic training algorithms in which error function values are allowed to increase at some epochs. To this end, we argue that the current error function value must satisfy a nonmonotone criterion with respect to the maximum error function value of the M previous epochs, and we propose a subprocedure to dynamically compute M. The nonmonotone strategy can be incorporated in any batch training algorithm and provides fast, stable, and reliable learning. Experimental results in different classes of problems show that this approach improves the convergence speed and success percentage of first-order training algorithms and alleviates the need for fine-tuning problem-depended heuristic parameters.
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http://dx.doi.org/10.1109/TNN.2002.804225 | DOI Listing |
Cogn Emot
January 2025
Equipe de Recherche Contextes et Acteurs de l'Education (ERCAé), Université d'Orléans, Orléans, France.
Recent research has revealed the widespread effects of emotion on cognitive functions and memory. However, the influence of emotional valence on verbal short-term memory remains largely unexplored, especially in children. This study measured the effect of emotional valence on word immediate serial recall in 4-6-year-old French children ( = 124).
View Article and Find Full Text PDFAdv Exp Med Biol
January 2025
Department of Optometry, University of Benin, Benin City, Nigeria.
Contact lenses have become integral tools in the realm of ocular therapeutics, extending beyond their primary function of refractive correction to encompass a diverse array of therapeutic applications. This review explores the evolving role of contact lenses in managing various ocular conditions, highlighting their efficacy in enhancing patient outcomes. Initially developed to correct refractive errors, contact lenses now serve as effective vehicles for delivering medications directly to the ocular surface, offering targeted treatment for conditions such as dry eye syndrome and corneal ulcers.
View Article and Find Full Text PDFProtein Sci
February 2025
Department of Biotechnology and Bioengineering, Sandia National Laboratories, Livermore, California, USA.
Engineered monoclonal antibodies have proven to be highly effective therapeutics in recent viral outbreaks. However, despite technical advancements, an ability to rapidly adapt or increase antibody affinity and by extension, therapeutic efficacy, has yet to be fully realized. We endeavored to stand-up such a pipeline using molecular modeling combined with experimental library screening to increase the affinity of F5, a monoclonal antibody with potent neutralizing activity against Venezuelan Equine Encephalitis Virus (VEEV), to recombinant VEEV (IAB) E1E2 antigen.
View Article and Find Full Text PDFPsychiatry Clin Neurosci
January 2025
Division of Digital Psychiatry, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Aim: Individuals living with schizophrenia experience significant impairments in social functioning. As a major clinical outcome, social functioning requires appropriate measurement tools that can capture its dynamic nature. Digital phenotyping, using smartphone technology to collect high volume ecologically valid data, can potentially capture these facets.
View Article and Find Full Text PDFProtein Sci
February 2025
York Structural Biology Laboratory, Department of Chemistry, University of York, York, UK.
Tryptophan mannosylation, the covalent addition of an α-ᴅ-mannose sugar to a tryptophan side chain, is a post-translational modification (PTM) that can affect protein stability, folding, and interactions. Compared to other forms of protein glycosylation, it is relatively uncommon but is affected by conformational anomalies and modeling errors similar to those seen in N- and O-glycans in the Protein Data Bank (PDB). In this work, we report methods for detecting, building, and improving mannose structures linked to tryptophans.
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