Five new dibenzylbutane type lignans (1-5) were isolated from the stem bark of Iryanthera lancifolia. Their structures were determined by extensive 1D and 2D NMR spectroscopic studies and chemical evidence. Seventeen of the isolated compounds were tested for their estrogenic activities in the estrogen responsive human breast cancer cell line MCF-7 BUS using the E-Screen proliferation assay. Cell proliferation was evaluated by the SRB assay to calculate the estrogenic parameters. The majority of the compounds induced a mitogenic response. This effect, given as Relative Proliferative Effect (RPE) to reference estrogen 17beta-estradiol (E(2)), ranged between 14% and 84%.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmc.2007.12.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Structure and estrogenic activity of new lignans from Iryanthera lancifolia.
Bioorg Med Chem
March 2008
Instituto Universitario de Bio-Orgánica Antonio González, Avda. Astrofísico Fco, Sánchez 2, 38206 La Laguna, Tenerife, Spain.
Five new dibenzylbutane type lignans (1-5) were isolated from the stem bark of Iryanthera lancifolia. Their structures were determined by extensive 1D and 2D NMR spectroscopic studies and chemical evidence. Seventeen of the isolated compounds were tested for their estrogenic activities in the estrogen responsive human breast cancer cell line MCF-7 BUS using the E-Screen proliferation assay.
View Article and Find Full Text PDFAntimicrobial activity of selected Peruvian medicinal plants.
J Ethnopharmacol
October 2003
Departamento de Química, Pontificia Universidad Católica del Perú, Aptdo. Postal 1761, Lima 100, Peru.
The antimicrobial activity of 36 ethanol extracts from 24 plants, all of them currently used in the Peruvian traditional medicine for the treatment of several infectious and inflammatory disorders, was tested by means of the agar-well diffusion assay against four bacteria (Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa) and four fungi (Candida albicans, Trichophyton mentagrophytes, Microsporum gypseum and Sporothrix schenckii). Twenty-five (69%) extracts showed some degree of antimicrobial activity against at least one microorganism. The plants with the greatest antimicrobial activity were Cestrum auriculatum L.
View Article and Find Full Text PDFDihydrochalcones and flavonolignans from Iryanthera lancifolia.
J Nat Prod
November 1999
Instituto de Qu¿imica, Universidade de Såo Paulo, C.P. 26077, CEP 05599-970, Såo Paulo-SP, Brazil, Instituto de Qu¿imica, Universidade Estadual Paulista, C.P. 355, CEP 14800-900, Araraquara-SP, Brazil, and Faculdade de Ci¿enc.
An extract from the pericarps of I. lancifolia afforded two dihydrochalcones (1 and 2) and two flavonolignans (3 and 4), with compounds 2-4 being of novel structure. The antioxidant activities of compounds 1-4 were evaluated through the measurement of malondialdehyde production, and Q(1/2) (concentration necessary for 50% inhibition of autoxidation) data were calculated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!