Synthesis of potent pyrrolidine influenza neuraminidase inhibitors.

Bioorg Med Chem Lett

Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 200 Abbott Park Road, AP-52N, Abbott Park, IL 60064, USA.

Published: March 2008

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Article Abstract

The synthesis of several pyrrolidine inhibitor analogs is described that possess nanomolar in vitro potencies against the neuraminidase enzymes expressed by the B/Memphis/3/89 and A/N1/PR/8/34 influenza strains.

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http://dx.doi.org/10.1016/j.bmcl.2008.01.048DOI Listing

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