Patients who dislocate their mandible often present to the Emergency Department for care. Dislocation can occur after a variety of activities that hyperextend the mandible or open the mouth widely, such as yawning, laughing, or taking a large bite. Anterior dislocation is the most common type, in which the condylar head of the mandible dislocates out of the glenoid fossa anterior to the articular eminence of the temporal bone. These dislocations are often complicated by muscle spasm and trismus, making reduction more difficult. The emergency physician can often reduce the anterior mandibular dislocation with or without procedural sedation or local anesthesia. A variety of methods are available for closed reduction, including the classic approach and various alternatives such as the recumbent, posterior, and ipsilateral approaches, as well as the wrist pivot method, alternative manual technique, and gag reflex induction. This article will review the pathophysiology and clinical presentation of acute mandibular dislocations, as well as discuss the various closed reduction methods available for the practitioner.
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http://dx.doi.org/10.1016/j.jemermed.2007.06.037 | DOI Listing |
Cureus
January 2025
Research and Development, Encoll Corporation, Fremont, USA.
The increased cost and morbidity associated with diabetic foot ulcers (DFUs) place a substantial strain on the entire global healthcare system. In this trial, 24 subjects with a chronic DFU, Wagner grade 1 (University of Texas grade 1A), were treated with Standard of Care (SOC) therapy and randomized, one-half to receive advanced high-purity Type-I collagen-based skin substitute (HPTC; manufactured by Encoll Corp., Fremont, CA, USA), and the other half to receive a dehydrated human amnion/chorion membrane (dHACM) or viable cryopreserved human placental membrane (vCHPM).
View Article and Find Full Text PDFNanoscale
January 2025
Institute of Hepatobiliary and Pancreatic Surgery, Department of Hepatobiliary and Pancreatic Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200120, P. R. China.
The mode of energy transfer between photosensitizers and oxygen determines the yield of singlet oxygen (O), crucial for photodynamic therapy (PDT). However, the aggregation of photosensitizers promotes electron transfer while inhibiting pure energy transfer, resulting in the generation of the hypotoxic superoxide anion (O) and consumption of substantial oxygen. Herein, we achieve the reduction of the aggregation of photosensitizers to inhibit electron transfer through classical chemical crosslinking, thereby boosting the production of O.
View Article and Find Full Text PDFBackground: Multiple approaches exist for operative fixation of metacarpal fractures; with common treatments including lag screw fixation or open-reduction internal fixation (ORIF) with plates and screws. Recently, the adaptation of intramedullary screw (IMS) placement has allowed for an essentially closed approach with stable fixation and theoretically improved outcomes. Thus, we sought to compare such approaches to ultimately determine the superior method for achieving the goal of return to normal function.
View Article and Find Full Text PDFCancer Metab
January 2025
Department of Cardiovascular medicine, Jinshan Hospital, Fudan University, Shanghai, 201508, China.
The Warburg effect, characterized by the shift toward aerobic glycolysis, is closely associated with the onset and advancement of tumors, including multiple myeloma (MM). Nevertheless, the specific regulatory mechanisms of glycolysis in MM and its functional role remain unclear. In this study, we identified that growth differentiation factor 15 (GDF15) is a glycolytic regulator, and GDF15 is highly expressed in MM cells and patient samples.
View Article and Find Full Text PDFJ Gynecol Obstet Hum Reprod
January 2025
Bichat Hospital, Paris, France; University Paris Cité, Paris, France.
Background: Vaginal cuff closure is an important step in hysterectomy. To date, the literature and data on this procedure are inconsistent, and the optimal approach (i.e.
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