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Dedicator of Cytokinesis 2 regulates cytoskeletal actin dynamics and is essential for platelet biogenesis and functions.
Cardiovasc Res
January 2025
Department of Pharmacology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Aims: Dedicator of Cytokinesis 2 (DOCK2), a member of the DOCK family of Guanine nucleotide exchange factors that specifically act on the Rho GTPases including Rac and Cdc42, plays pivotal roles in the regulation of leukocyte homeostasis. However, its functions in platelets remain unknown.
Methods And Results: Using mice with genetic deficiency of DOCK2 (Dock2-/-), we showed that Dock2-/-mice exhibited a macrothrombocytopenic phenotype characterized as decreased platelet count and enlarged platelet size by transmission electron microscopy.
The role of eosinophil counts and megakaryocyte nuclei for distinction of acute and chronic immune thrombocytopenic purpura.
Blood Coagul Fibrinolysis
November 2024
Department of Pediatric Hematology, Gazi University School of Medicine, Ankara, Turkey.
Objective: Immune thrombocytopenic purpura (ITP), the most common cause of thrombocytopenia, is clinically classified as acute and chronic. This study aimed to distinguish between acute/chronic ITP parameters examined at diagnosis via complete blood count (CBC), peripheral blood (PB) and bone marrow aspirate (BMA) smears. It would also contribute to early treatment options, cost-effective policies, and the life quality of patients.
View Article and Find Full Text PDFPlatelet's plea to Immunologists: Please do not forget me.
Int Immunopharmacol
December 2024
Department of Surgery, Laboratory of Tumor Immunology and Immunotherapy, Medical Education Building-C, Morehouse School of Medicine, 720 Westview Drive, Atlanta, GA 30310 USA.
Platelets are non-nucleated mammalian cells originating from the cytoplasmic expulsion of the megakaryocytes. Megakaryocytes develop during hematopoiesis through megakaryopoiesis, whereas platelets develop from megakaryocytes through thrombopoiesis. Since their first discovery, platelets have been studied as critical cells controlling hemostasis or blood coagulation.
View Article and Find Full Text PDFRegulatory T cells-related gene in primary sclerosing cholangitis: evidence from Mendelian randomization and transcriptome data.
Genes Immun
December 2024
Department of Gastroenterology, The Central Hospital of Hengyang City, Hengyang, Hunan Province, PR China.
The present study utilized large-scale genome-wide association studies (GWAS) summary data (731 immune cell subtypes and three primary sclerosing cholangitis (PSC) GWAS datasets), meta-analysis, and two PSC transcriptome data to elucidate the pivotal role of Tregs proportion imbalance in the occurrence of PSC. Then, we employed weighted gene co-expression network analysis (WGCNA), differential analysis, and 107 combinations of 12 machine-learning algorithms to construct and validate an artificial intelligence-derived diagnostic model (Tregs classifier) according to the average area under curve (AUC) (0.959) in two cohorts.
View Article and Find Full Text PDFIntegrative Transcriptomic Analysis of Peripheral Blood Monocytes in Systemic Sclerosis and Shared Pathogenic Pathways in Autoimmune Diseases.
Arch Med Res
August 2024
Division of Rheumatology, School of Medicine, University of California at Los Angeles, California, USA.
Article Synopsis
- Systemic sclerosis (SSc) is an autoimmune disease that is often overlooked compared to others like rheumatoid arthritis, and this study examines gene expression and immune cell profiles in patients with SSc.
- * RNA sequencing data from 119 patients and healthy controls revealed 1,148 differentially expressed genes (DEGs) unique to SSc, indicating altered megakaryocyte processes and decreased neutrophil function.
- * The findings point to shared pathogenic pathways in autoimmune diseases, specifically emphasizing megakaryocyte proliferation, and suggest potential new targets for SSc treatment.*
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