AI Article Synopsis
- The study introduces a new index for assessing voiding dysfunction (D) based on free uroflow (FF), aiming to improve management of benign prostatic enlargement (BPE) patients.
- The index D shows greater precision than the traditional maximum flow rate (Q(max)), being unaffected by urine volume or short-term flow disruptions.
- Results indicate D effectively reflects treatment response, with significant changes post-surgery compared to medication, providing better insight into a patient’s voiding status.
Article Abstract
Objectives: To present the theoretical development and clinical relevance of a new index of voiding dysfunction (D) based purely on free uroflow (FF), to assist in the management of patients with benign prostatic enlargement (BPE), and to compare its merits against the maximum flow rate (Q(max)).
Patients And Methods: In the Valentini-Besson-Nelson (VBN) micturition model for men, two variables characterize urethral obstruction, i.e. the prostatic urethral counter-pressure pucp and the detrusor force coefficient k. D can be obtained from a FF assuming a normal detrusor (k = 1). Clinically, multiple FF from patients entered in a double-blind pharmacological trial provided variations of D over time. D values were also compared before and after transurethral resection of the prostate (TURP).
Results: In 137 patients with BPE from several institutions, D was more precise than Q(max) because D is independent of volume and of perturbations of short duration during the flow. The change in D was proportionate to the invasiveness of treatment; the mean (SD) decrease after TURP was 14.6 (8.7) cmH(2)O, vs 8.1 (5.4) cmH(2)O after 90 days of alpha-blocker intake. Retrospectively, the range of D fitted with the clinician's decision, i.e. pharmacological trial (16-31 cmH(2)O) vs TURP (27-46 cmH(2)O; P < 0.001).
Conclusion: The new index (D), deduced from the VBN analysis of only FF, is responsive to treatment. This simple calculation offers an insight into the voiding status of a patient with BPE beyond that obtained by Q(max) alone.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1464-410X.2008.07460.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pulmonary artery (PA) flow analysis is crucial for understanding the progression of pulmonary hypertension (PH). We hypothesized that PA flow characteristics vary according to PH etiology. In this study, we used 4D flow cardiovascular magnetic resonance imaging (CMR) to compare PA flow velocity and wall shear stress (WSS) between patients with pulmonary arterial hypertension (PAH) and those with heart failure with preserved ejection fraction and pulmonary hypertension (PH-HFpEF).
View Article and Find Full Text PDFSynergistic Anticancer Efficacy of Curcumin and Doxorubicin Combination Treatment Inducing S-phase Cell Cycle Arrest in Triple-Negative Breast Cancer Cells: An In Vitro Study.
Cureus
December 2024
Department of Biochemistry, Era's Lucknow Medical College and Hospital, Era University, Lucknow, IND.
Background: Curcumin (Cur) is a polyphenol phyto-compound found in turmeric () that inhibits tumorigenesis by introducing apoptosis and restricting cell survival and proliferation. This in vitro research article focuses on the pharmacodynamic interactions of Cur combined with the commercial drug doxorubicin (Doxo) to enhance the cytotoxicity of Doxo at lower doses against triple-negative breast cancer cells (MDA-MB-231) with the chemo-protective effect against normal HEK293 cells. In this study, we observed the dose-dependent cytotoxicity, increased reactive oxygen species (ROS) generation, and increased chromatin condensation in combination doses compared to single doses.
View Article and Find Full Text PDFInfluence law of air flow and water immersion duration on the risk of secondary oxidation spontaneous combustion of coal.
Sci Rep
January 2025
School of Civil and Transportation Engineering, Ningbo University of Technology, NiBo, 315211, China.
To further elucidate the variations of secondary oxidation spontaneous combustion risk of lignite under different air flows and immersion time. Secondary oxidation experiments of short-term water-immersed coal and long-term water-immersed coal were conducted under four air flows. The results show that, the presence of a temperature inflection point during primary oxidation process, when coal temperature exceeds it, both the oxygen consumption rate and heat release intensity of long-term water-immersed coal are lower, furthermore, decrease in air flow leads to reduction in the temperature inflection point.
View Article and Find Full Text PDFElimination of nickel ions in a packed column using clamshell waste as an adsorbent.
Sci Rep
January 2025
Department of Nuclear and Renewable Energy Sources, Ural Federal University, Yekaterinburg, 620002, Russia.
The present investigation assessed the viability of utilizing a powdered clam shell in continuous adsorption to eliminate nickel ions from simulated wastewater. The breakthrough curves (BTC) were analyzed by altering the Q (inlet flow rate) in a glass column (ID 5 cm, H 35 cm) with a multi-port and filled with the powdered clamshell adsorbent (PCSA). The PCSA's nickel adsorption efficiency was maximum (87.
View Article and Find Full Text PDFIntroducing an index on prediction of post-revascularization cerebral infarction using preoperative CT perfusion parameters in moyamoya disease.
Insights Imaging
January 2025
Department of Radiology, The First Affiliated Hospital of Wannan Medical College, Wuhu, PR China.
Objective: To determine the value of preoperative CT perfusion (CTP) parameters for prediction of post-revascularization cerebral infarction (post-CI) in adults with moyamoya disease (MMD).
Methods: This retrospective study included 92 adults with MMD who underwent surgical revascularization. Preoperative quantitative CTP parameters, including cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), time to drain (TTD), and transit time to maximum of the residue function (Tmax), along with clinical data, were compared between the groups with and without post-CI.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!