AI Article Synopsis
- An 84-year-old woman developed acute respiratory distress syndrome (ARDS) after taking shiniseihaito for rhinitis treatment, indicating a severe allergic reaction.
- The condition improved significantly with corticosteroid therapy, supporting the diagnosis of an allergic response triggered by the drug.
- This case highlights the need for careful monitoring when prescribing shiniseihaito, now recorded as the seventh instance of drug-induced lung injury linked to this medication.
Article Abstract
We present a case of acute respiratory distress syndrome (ARDS) caused by allergic reactions to shiniseihaito. An 84-year-old woman showed acute interstitial pneumonia followed by ARDS after taking shiniseihaito for the treatment of rhinitis. The ARDS were markedly improved with corticosteroid therapy. This case was diagnosed as being induced by shiniseihaito because it was compatible with 4 of 5 of Camus's criteria. The stimulation index of the drug lymphocyte stimulation test with shiniseihaito increased after corticosteroid therapy had been tapered and suggested that the mechanism of acute interstitial pneumonia in this case was allergic reaction induced by shiniseihaito. This is the seventh reported case of drug induced lung injury by shiniseihaito. We recommend careful observation when this medicine is prescribed.
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