The ethyl acetate extract from the seeds of Herpetospermum caudigerum was found to show protective effects on carbon tetrachloride (CCl(4)) and thioacetamide (TAA)-induced acute hepatic injuries in mice. From the ethyl acetate extract, two new coumarins, herpetolide A (1) and herpetolide B (2), along with four known compounds, herpetone (3), dehydrodiconiferyl alcohol (4), 2,4-dihydroxypyrimidine (5) and stigmasterol (6) were isolated. The structures of the new coumarins were elucidated on the basis of chemical and physicochemical evidences. Herpetone exhibited protective effects on CCl(4)-induced hepatocyte injury.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1248/cpb.56.192 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Preparation and intestinal absorption mechanism of self-assembled nanoparticles of Herpetospermum caudigerum].
Zhongguo Zhong Yao Za Zhi
June 2024
Key Laboratory of Modern Preparation of Traditional Chinese Medicine,Ministry of Education,Jiangxi University of Chinese Medicine Nanchang 330004, China Department of Pharmacy,Air Force Medical Center,PLA, Air Force Medical University Beijing 100142, China.
In this experiment, the micro-precipitation method was used to prepare self-assembled nanoparticles of Herpetospermum caudigerum Wall.(MP-SAN). The process was optimized using average particle size and polydispersity index(PDI)as evaluation indexes.
View Article and Find Full Text PDFProgress based on a multi-omics research strategy in the biosynthesis and modernization of active ingredients of Herpetospermum pedunculosum seeds.
Fitoterapia
September 2024
School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 613100, PR China. Electronic address:
Article Synopsis
- Herpetospermum pedunculosum seeds have shown pharmacological activities such as hepatoprotection, anti-inflammation, anti-gout, and antibacterial effects, highlighting their potential in drug discovery.
- The research details the complex biosynthetic pathways of terpenoids and lignans in H. pedunculosum, using multi-omics strategies to identify key enzyme genes involved in producing biologically active compounds.
- The review emphasizes the plant's potential as an antidiabetic agent and lays the groundwork for future therapeutic agent discovery from natural sources.
Integrative analysis of the metabolome and transcriptome provides insights into the mechanisms of lignan biosynthesis in Herpetospermum pedunculosum (Cucurbitaceae).
BMC Genomics
April 2024
Engineering Research Center of Sichuan-Tibet Traditional Medicinal Plant, Chengdu University, 610106, Chengdu, China.
Article Synopsis
- Herpetospermum pedunculosum is a traditional Chinese herbal medicine known for its lignans, which have antioxidant and liver-protective properties, but the process of lignan biosynthesis in this plant was previously not well understood.
- Through metabolomic and transcriptomic analyses, researchers found that the levels of lignan-related metabolites and the expression of associated genes differ significantly between the green mature and yellow mature stages, with most being more active in the yellow mature stage.
- The study proposed a lignan biosynthesis pathway and identified key transcription factors and the enzyme 4-Coumarate: CoA ligase (4CL) involved in lignan production, contributing to better insights into seed lignan biosynthesis for future
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Research (Wash D C)
November 2023
Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.
Non-alcoholic fatty liver disease, especially nonalcoholic steatohepatitis (NASH), is a leading cause of cirrhosis and liver cancer worldwide; nevertheless, there are no Food and Drug Administration-approved drugs for treating NASH until now. Peroxisome proliferator-activated receptor alpha (PPARα) is an interesting therapeutic target for treating metabolic disorders in the clinic, including NASH. Herpetrione, a natural lignan compound isolated from Tibetan medicine , exerts various hepatoprotective effects, but its efficacy and molecular mechanism in treating NASH have not yet been elucidated.
View Article and Find Full Text PDFEthanol extract of Herpetospermum caudigerum Wall ameliorates psoriasis-like skin inflammation and promotes degradation of keratinocyte-derived ICAM-1 and CXCL9.
J Integr Med
November 2023
Engineering Research Center of Sichuan-Xizang Traditional Medicinal Plant, Chengdu University, Chengdu 610106, Sichuan Province, China; Institute of Cancer Biology and Drug Discovery, Chengdu University, Chengdu 610106, Sichuan Province, China; School of Food and Biological Engineering, Chengdu University, Chengdu 610106, Sichuan Province, China. Electronic address:
Objective: To explore whether the ethanol extract of Herpetospermum caudigerum Wall (EHC), a Xizang medicinal plant traditionally used for treating liver diseases, can improve imiquimod-induced psoriasis-like skin inflammation.
Methods: Immunohistochemistry and immunofluorescence staining were used to determine the effects of topical EHC use in vivo on the skin pathology of imiquimod-induced psoriasis in mice. The protein levels of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and interleukin-17A (IL-17A) in mouse skin samples were examined using immunohistochemical staining.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!