The use of a resonant helical coil with predominantly axial electric fields for regional hyperthermia in the abdomen and pelvis is addressed. The Helix-I applicator, which consists of a three-turn, 36-cm-long, oval-wound helical coil measuring 60 and 43 cm along its major and minor axes, respectively, is described, and specific absorption rate (SAR) measurements for the device are reported. Measurements of the E-field are also described. Specific absorption patterns for the Helix, determined by transient temperature measurements using a gel phantom, and by E(2)-field scans using a liquid phantom, are in general agreement. The general agreement of electric power intensity distribution, inside and outside the phantom, with corresponding SAR distributions obtained from transient temperature data, ensures reliability of the distribution patterns. The E(2) contours provide a clear picture of hot and cold spots as well as the nature of the general distribution.
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http://dx.doi.org/10.1109/51.57872 | DOI Listing |
Carbohydr Polym
March 2025
School of Public Health, Ningxia Medical University, Yinchuan 750004, Ningxia, China. Electronic address:
Intestinal injury and microbiota disorder take part in the development of UC. In this research, we obtained an arabinogalactan (LBP-m) from Lycium barbarum and firstly characterized its physicochemical properties. LBP-m was a homogeneous polysaccharide (172 kDa) consisted of Ara, Gal, Glc, GalA, and GlcA with a mole ratio of 1.
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January 2025
Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA; Department of Medicine, Division of Infectious Diseases, Brigham & Women's Hospital, Boston, MA, USA; Center for Integrated Solutions in Infectious Diseases, Broad Institute of Harvard and MIT, Cambridge, MA, USA; Howard Hughes Medical Institute, Boston, MA, USA. Electronic address:
Nipah virus (NiV) is a bat-borne, zoonotic RNA virus that is highly pathogenic in humans. The NiV polymerase, which mediates viral genome replication and mRNA transcription, is a promising drug target. We determined the cryoelectron microscopy (cryo-EM) structure of the NiV polymerase complex, comprising the large protein (L) and phosphoprotein (P), and performed structural, biophysical, and in-depth functional analyses of the NiV polymerase.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
College of Engineering, China Agricultural University, Beijing 100083, China. Electronic address:
Bacteriocins, naturally derived antimicrobial peptides, are considered promising alternatives to traditional preservatives and antibiotics, particularly in food and medical applications. Despite extensive research on various bacteriocins, cyclic varieties remain understudied. This study introduces Gassericin GA-3.
View Article and Find Full Text PDFbioRxiv
November 2024
Laboratory of Structural Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 South Dr., Bethesda, MD, 20892, USA.
SSNA-1 is a fibrillar protein localized at the area where dynamic microtubule remodeling occurs including centrosomes. Despite the important activities of SSNA1 to microtubules such as nucleation, co-polymerization, and lattice sharing microtubule branching, the underlying molecular mechanism have remained unclear due to a lack of structural information. Here, we determined the cryo-EM structure of SSNA-1 at 4.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Textile and Clothing College, Qingdao University, Qingdao 266071, China.
Fiber-based strain sensors, as wearable integrated devices, have shown substantial promise in health monitoring. However, current sensors suffer from limited tunability in sensing performance, constraining their adaptability to diverse human motions. Drawing inspiration from the structure of the spiranthes sinensis, this study introduces a unique textile wrapping technique to coil flexible silver (Ag) yarn around the surface of multifilament elastic polyurethane (PU), thereby constructing a helical structure fiber-based strain sensor.
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