The paper considers a clinical role of crystalluria and its relation to urolithiasis. Examination of 185274 cases of symptomless crystalluria in the citizens of Kharkov and Kharkov region revealed oxalic-calcic urinary crystals in 12.2%, urate crystals in 3.6% and phosphate crystals in 1.2% of the examinees. Oxalic-calcic crystalluria in urgent urinary conditions occurs significantly more frequently (25.8%). Crystalluria was studied in 372 nephrolithiasis patients. Urinary crystals were found in 44.0%. The type of the crystals corresponded to chemical composition of the urinary concrements. Oxalic-calcic nephrolithiasis was detected in a younger group of patients (aged 37.3 +/- 1.3). It is suggested to consider crystalluria as microurolithiasis indicating predisposition to lithogenesis in the urinary tract and as a preclinical manifestation of urolithiasis.
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FASEB J
January 2025
Department of Hematology, Nephrology, and Rheumatology, Graduate School of Medicine, Akita University, Akita, Japan.
Various tubular diseases in patients with multiple myeloma (MM) are caused by monoclonal immunoglobulin light chains (LCs). However, the physicochemical characteristics of the disease-causing LCs contributing to the onset of MM-associated tubular diseases remain unclear. We herein report a rare case of MM-associated combined tubulopathies: non-crystalline light chain proximal tubulopathy (LCPT) and crystalline light chain cast nephropathy (LCCN).
View Article and Find Full Text PDFCurr Pharm Biotechnol
December 2024
LMAE, Faculty of Sciences Exactes, University of Mascara, B.P. 763, Mascara, Algeria.
Introduction: A stone is a compact mass of one or more crystallised substances. The essential mechanism of stone formation is an excessive concentration of poorly soluble compounds in the urine. In excessive concentration, these compounds precipitate into crystals, which then aggregate to form a stone.
View Article and Find Full Text PDFIntroduction: The use of urine cytobacteriological examination is a common and essential practice in medicine which helps guide therapeutic management in case of urinary tract infection. The cytological examination of urine samples can be done using the manual (microscopic) or automated technique. The automated approach, which involves the use of artificial intelligence, is faster, more reliable, and more efficient for laboratories.
View Article and Find Full Text PDFKidney Int
January 2025
Service of Nephrology, Ospedale Regionale di Locarno "La Carità," Ente Ospedaliero Cantonale, Locarno, Switzerland.
Clin Ther
December 2024
Department of Infectious Diseases, CHU Clermont-Ferrand, Clermont-Ferrand, France. Electronic address:
Purpose: High doses of amoxicillin are recommended to treat severe infections such as endocarditis. Amoxicillin causes dose-dependent toxicities, in particular crystal nephropathy. Toxicity could be avoided by monitoring of amoxicillin trough plasma concentrations (ATPC).
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