[Protective effect of total flavonoid of Herba Pyrolae on acute myocardial ischemic injury in rats].

Objective: To investigate the protective effect of Total Flavonoid of Herba Pyrolae(TFHP) on acute myocardial ischemic injury in rats.

Methods: Acute myocardial ischemic models were established by i. v. injection of pituitrin and the ligation of left descending coronary artery in rats. ECG of the rat was recorded, myocardial ischemic size was evaluated, and activites of creatine phosphokinase( CK), lactate dehydrogenase (LDH) and superoxide dismutase (SOD), level of malondialdehyde (MDA) in the rat serum were determined.

Results: In comparison with the model control, TFHP significantly reduced the incidence of ischemic arrhythmia induced by pituitrin, size of myocardial infarction, release of myocardial CK and LDH caused by the ligation of left descending coronary artery in rats. The primary study of action mechanism showed that TFHP decreased MDA level and increased SOD activity in the rat serum.

Conclusion: TFHP provide a protective effect on acute myocardial ischemic injury via antioxidation.