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Revisiting VH1 phosphatase at the time of monkeypox: back to the spotlight.
Biochem Soc Trans
August 2023
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, U.S.A.
Article Synopsis
- * The vaccinia H1 (VH1) phosphatase is a unique protein that can act on different types of phosphorylated residues and plays a crucial role in viral replication and immune response.
- * VH1 is a promising target for anti-poxvirus drug development due to its conservation across poxviruses and differences from a related human phosphatase, making it a viable candidate for creating inhibitors that disrupt its dimer structure.
Protein Tyrosine Phosphatase Biochemical Inhibition Assays.
Bio Protoc
September 2022
NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 N Torrey Pines Rd, La Jolla, CA 92037, USA.
Disturbance of the dynamic balance between protein tyrosine phosphorylation and dephosphorylation, modulated by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), is known to be crucial for the development of many human diseases. The discovery of agents that restore this balance has been the subject of many drug research efforts, most of which have focused on tyrosine kinase inhibitors (TKIs), resulting in the development of more than 50 FDA-approved TKIs during the past two decades. More recently, accumulating evidence has suggested that members of the PTP superfamily are also promising drug targets, and efforts to discover tyrosine phosphatase inhibitors (TPIs) have increased dramatically.
View Article and Find Full Text PDFBrain Hypoxia Is Associated With Neuroglial Injury in Humans Post-Cardiac Arrest.
Circ Res
August 2021
Division of Critical Care Medicine, Department of Medicine, Vancouver General Hospital (S.T., D.F., N.A.F., D.E.G., M.S.S.), University of British Columbia, Vancouver, Canada.
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View Article and Find Full Text PDFProtein tyrosine phosphatase 1B inhibitory activities of ursane-type triterpenes from Chinese raspberry, fruits of Rubus chingii.
Chin J Nat Med
January 2019
Faculty of Pharmaceutical Sciences, Toho University, Chiba 274-8510, Japan.
Protein tyrosine phosphatase 1B (PTP1B) has led to an intense interest in developing its inhibitors as anti-diabetes, anti-obesity and anti-cancer agents. The fruits of Rubus chingii (Chinese raspberry) were used as a kind of dietary traditional Chinese medicine. The methanolic extract of R.
View Article and Find Full Text PDFIdentification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors.
J Enzyme Inhib Med Chem
December 2018
c Faculty of Pharmaceutical Sciences , Toho University, Funabashi , Japan.
Protein tyrosine phosphatase 1B (PTP1B) is an attractive molecular target for anti-diabetes, anti-obesity, and anti-cancer drug development. From the seeds of Silybum marianum, nine flavonolignans, namely, silybins A, B (1, 2), isosilybins A, B (3, 4), silychristins A, B (5, 6), isosilychristin A (7), dehydrosilychristin A (8), and silydianin (11) were identified as a novel class of natural PTP1B inhibitors (IC 1.3 7-23.
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