Age- and sex-related incidence of surgically treated primary hyperparathyroidism.

World J Surg

Division of Endocrine Surgery, Department of Surgery, University of Michigan, TC2920F University Hospital, 1500 E. Medical Center Dr, Ann Arbor, Michigan 48109-5331, USA.

Published: May 2008

Background: Primary hyperparathyroidism (1 degrees HPT) is reported most often in women over the age of 50. Beyond that, little is known about the epidemiology of this condition, and no studies have specifically examined the age and gender distribution of patients with 1 degrees HPT.

Methods: We analyzed patients from the Nationwide Inpatient Sample (NIS), a 20% random sample of all hospital stays from 2000-2004, and also from the University of Michigan endocrine surgery database from 1999-2005. Surgically treated 1 degrees HPT was used as a surrogate marker for 1 degrees HPT. An age- and sex-based frequency distribution was computed for each dataset.

Results: A total of 7,513 females and 2,677 males who underwent surgery for 1 degrees HPT in the 5-year period 2000 through 2004 were reported in the NIS. At the University of Michigan from 1999 through 2005, 790 females and 276 males underwent parathyroidectomy for 1 degrees HPT. In both datasets, the frequency of 1 degrees HPT began to rise slowly in both sexes at age 11 and increased more rapidly among females than males beginning at age 21-25 (NIS) and 26-30 (UM). Incidence curves for both women and men in both databases were similar in shape and unipolar in configuration. Peak incidence was at age 56-60 (NIS) and 61-65 (UM) in females and age 56-60 in males (both datasets). The female:male ratio was noted to rise steadily among the NIS patients until perimenopausal age, after which it became stable for the next 20 years before decreasing again. No change in the female:male ratio over time was seen among the UM patients.

Conclusions: Primary HPT occurs more frequently in females than in males at all ages. The incidence increases steadily after age 25 in both sexes. The female:male ratio does not change during the peri- and postmenopausal years. This information should stimulate new hypotheses to explain the difference in the incidence of 1 degrees HPT between men and women.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00268-007-9427-2DOI Listing

Publication Analysis

Top Keywords

degrees hpt
28
femalemale ratio
12
surgically treated
8
primary hyperparathyroidism
8
degrees
8
hpt
8
age
8
university michigan
8
males underwent
8
females males
8

Similar Publications

Objectives: Lateral semicircular canal BPPV (LSC-BPPV) is diagnosed with the Head Yaw Test (HYT) by observing nystagmus direction and comparing the nystagmus intensity on both sides according to Ewald's laws. Head Pitching Test (HPT) is a diagnostic maneuver performed in the upright position by bending the patient's head forward (bowing) and backward (leaning) and observing the evoked nystagmus. We aimed to assess the sensitivity of HPT in correctly diagnosing LSC-BPPV through the quantitative measurement of Bowing and Leaning nystagmus slow-phase velocity (SPV).

View Article and Find Full Text PDF

Purpose: Comparing the efficacy and safety of programmed cell death protein-1 (PD-1) inhibitors combined with tyrosine kinase inhibitors (TKIs) with or without hepatic artery infusion chemotherapy (HAIC) in HBV-related advanced HCC and exploring prognostic predictors of the combined regimen.

Patients And Methods: A total of 194 patients diagnosed with HBV-related advanced HCC between 2020 and 2022 were included in the study, including 99 in the HAIC combined with PD-1 inhibitors plus TKIs (HPT group) and 95 in the PD-1 inhibitors plus TKIs (PT group). The efficacy was evaluated according to the tumor response rate and survival, and the safety was evaluated according to the adverse events.

View Article and Find Full Text PDF
Article Synopsis
  • MEN type 1 (MEN1) is an inherited disorder affecting tumor development in glands like parathyroid, pancreas, and pituitary, with an incidence rate of 2-10 cases per 100,000 individuals.
  • In a study involving 68 diagnosed patients and 84 relatives, researchers sequenced parts of the MEN1 gene to identify mutations and their prevalence.
  • The findings revealed a high prevalence of parathyroid tumors (87.5%), significant mutation rates among familial cases (90%) compared to sporadic cases (51%), and the discovery of seven novel mutations.
View Article and Find Full Text PDF

Infants' reorienting efficiency depends on parental autistic traits and predicts future socio-communicative behaviors.

Cereb Cortex

May 2024

Developmental and Cognitive Neuroscience Lab, Department of General Psychology, Via Venezia 8, University of Padova, 35131 Padova, Italy.

Attentional reorienting is dysfunctional not only in children with autism spectrum disorder (ASD), but also in infants who will develop ASD, thus constituting a potential causal factor of future social interaction and communication abilities. Following the research domain criteria framework, we hypothesized that the presence of subclinical autistic traits in parents should lead to atypical infants' attentional reorienting, which in turn should impact on their future socio-communication behavior in toddlerhood. During an attentional cueing task, we measured the saccadic latencies in a large sample (total enrolled n = 89; final sample n = 71) of 8-month-old infants from the general population as a proxy for their stimulus-driven attention.

View Article and Find Full Text PDF

The mutualistic network of plant-pollinator also involves interspecific pollination caused by pollinator sharing. Plant-pollinator networks are commonly based on flower visit observations, which may not adequately represent the actual pollen transfer between co-flowering plant species. Here, we compared the network structure of plant-pollinator interactions based on flower visits (FV) and pollen loads (PL) on the bodies of pollinators and tested how the degree of pollinator sharing in the two networks affected heterospecific pollen transfer (HPT) between plant species in a subalpine meadow.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!