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Characterisation of GPR17-expressing oligodendrocyte precursors in human ischaemic lesions and correlation with reactive glial responses.
J Pathol
February 2025
Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy.
White matter damage and subsequent demyelination significantly contribute to long-term functional impairment after ischaemic stroke. Identifying novel pharmacological targets to restore myelin integrity by promoting the maturation of oligodendrocyte precursor cells (OPCs) into new myelinating oligodendrocytes may open new perspectives for ischaemic stroke treatment. In this respect, previous studies highlighted the role of the G protein-coupled membrane receptor 17 (GPR17) as a key regulator of OPC differentiation in experimental models of brain injury, including ischaemic stroke.
View Article and Find Full Text PDFAutologous breast augmentation combining the harvesting of the Anterior Intercostal Artery Perforator (AICAP) and Lateral Intercostal Artery Perforator (LICAP) flaps in massive weight loss patient: A case report.
JPRAS Open
September 2024
Policlinico Umberto I, La Sapienza, Piazzale Aldo Moro 5, 00185 Roma, RM, Italy.
Patients undergoing bariatric surgical procedures usually exhibit breast ptosis due to the quick weight loss. In this type of patients, the mastopexy represents a challenge for plastic surgeons considering the abundance of dystrophic cutaneous tissue, the loss of subcutaneous tissue and the impossibility to employ heterologous devices in the setting of Italian public healthcare. In addition, it is necessary to consider that patients undergoing post-bariatric surgery have increasingly high expectations.
View Article and Find Full Text PDFUnravelling drivers of cutaneous squamous cell carcinoma in recessive dystrophic epidermolysis bullosa.
Hum Immunol
May 2024
St John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, Guy's Hospital, London SE1 9RT, UK. Electronic address:
Epidermolysis bullosa (EB) is an umbrella term for a group of rare inherited skin disorders characterised by mucocutaneous fragility. Patients suffer from blisters and chronic wounds that arise spontaneously or following minor mechanical trauma, often resulting in inflammation, scarring and fibrosis due to poor healing. The recessive form of dystrophic EB (RDEB) has a particularly severe phenotype and is caused by mutations in the COL7A1 gene, encoding the collagen VII protein, which is responsible for adhering the epidermis and dermis together.
View Article and Find Full Text PDFSymptomatic Calcifications after Mastectomy: A Rare Case Report with a Review of the Literature.
Medicina (Kaunas)
February 2024
Department of Surgery, Silesian Hospital in Opava, 746 01 Opava, Czech Republic.
: Symptomatic calcifications of the breast or skin after breast cancer surgery and adjuvant radiotherapy are a rare entity, with only a few case reports published worldwide, reducing the patient's quality of life, whilst asymptomatic calcifications are a common finding on imaging methods. : Herein, we present a rare case report of calcifications after mastectomy and post-mastectomy radiation therapy causing chronic inflammation with ulceration and fistula formation, with a two-step surgical approach consisting of excision with linear suture and excision with the reconstruction using a thoraco-epigastric flap. : To our knowledge, this is the first publication proving the feasibility of this therapy in patients with symptomatic dystrophic calcifications of the skin or the breast.
View Article and Find Full Text PDFRetrospective Study on Optimizing Breast Augmentation Outcomes in Transgender Patients: A Comprehensive Analysis of Tumescent Local Anesthesia Technique.
Aesthetic Plast Surg
October 2024
Plastic Surgery Unit, Department of Surgical, Microsurgical and Medical Sciences, University of Sassari, Sassari, Italy.
Article Synopsis
- Tumescent local anesthesia (TLA) is utilized to provide localized anesthesia and vasoconstriction during primary sub-muscular breast augmentations in transgender patients, with a modified approach reported from 2014 to 2021.
- A total of 20 transgender patients underwent surgery using a specific saline solution formula, with no instances of anesthesia-related complications, and a major complication rate of only 5%.
- The procedure is seen as beneficial for transgender women, promoting feminine characteristics while encouraging patients to fully understand the risks and benefits associated with breast augmentation.
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