AI Article Synopsis
- A study examined AGA IgA and IgG levels in 36 coeliac children on a gluten diet, testing their HLA antigens for correlations.
- All children were found to have AGA antibodies, but those without the DR3 or DR7 antigens had lower levels than those with them.
- This raises concerns that some coeliac patients may be misdiagnosed if testing is solely based on AGA levels, highlighting the condition's genetic diversity.
Article Abstract
Thirty-six coeliac children on gluten-containing diet were studied for AGA IgA and IgG levels. Patients were typed for HLA-A, -B, -C, -DR, -DQ antigens and data were analysed for any correlation between HLA-DR phenotype and AGA levels. AGA IgA and/or IgG were present in all these children. Subjects negative for DR3 or DR7 showed lower AGA levels than those DR3 + and/or DR7 positive. The data suggest that these patients could escape diagnosis if screening for those requiring intestinal biopsy is based only on AGA assay. The observation that coeliac children negative for DR3 and DR7 showed lower AGA levels is consistent with clinical and genetic heterogeneity of coeliac disease.
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