Denaturation transition of stretched DNA.

Phys Rev Lett

Department of Physics and Astronomy, University of Texas at Brownsville, 80 Fort Brown, Brownsville, TX, USA.

Published: January 2008

We generalize the Poland-Scheraga model to consider DNA denaturation in the presence of an external stretching force. We demonstrate the existence of a force-induced DNA denaturation transition and obtain the temperature-force phase diagram. The transition is determined by the loop exponent c, for which we find the new value c = 4 nu-1/2 such that the transition is second order with c = 1.85 < 2 in d = 3. We show that a finite stretching force F destabilizes DNA, corresponding to a lower melting temperature T(F), in agreement with single-molecule DNA stretching experiments.

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http://dx.doi.org/10.1103/PhysRevLett.100.018106DOI Listing

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