AI Article Synopsis
- The study analyzed the birth weight distribution of 201 infant leukemia cases against 440 non-cancer controls in Brazil from 1999 to 2005.
- Findings showed that infants weighing 3000-3999g had a 1.68 times higher risk, and those weighing 4000g or more had a 2.28 times higher risk of developing infant leukemia compared to the reference weight category of 2500-2999g.
- Adjusting for factors like gender and maternal exposure, the odds ratio for infants weighing 4000g or more remained significant at 1.30, indicating a strong association between high birth weight and increased risk of infant leukemia.
Article Abstract
In this paper, we compared the birth weight distribution among 201 infant leukaemia (IL) cases with that of 440 noncancer controls enrolled in Brazil in 1999-2005. Compared with the general population and the stratum 2500-2999 g as reference, IL cases weighing 3000-3999 g presented an odds ratio (OR) of 1.68 (95% CI: 1.03-2.76), and those of 4000 g or more, an OR of 2.28 (95% CI: 1.08-4.75), P trend<0.01. Using hospital-based controls, the OR for 4000 g or more, compared to 2500-2999 g, was 1.30 (95% CI: 1.02-1.43) after adjusting for confounders (gender, income, maternal age, pesticide and hormonal exposure during pregnancy). The results suggest that high birth weight is associated with increased risk of IL.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2243143 | PMC |
| http://dx.doi.org/10.1038/sj.bjc.6604202 | DOI Listing |
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