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RETRACTION: Effect of Oridonin on Experimental Animal Model of Bronchopulmonary Dysplasia.
J Cell Biochem
December 2024
S. Zhang, J. Wang, Z.
View Article and Find Full Text PDFEnhancing cancer therapy: advanced nanovehicle delivery systems for oridonin.
Front Pharmacol
December 2024
Institute of Urology, The Third Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, China.
Oridonin (ORI), an ent-kaurane diterpenoid derived from Rabdosia rubescens (Hemsl.) H.Hara, serves as the primary bioactive component of this plant.
View Article and Find Full Text PDFOridonin attenuates diabetic retinopathy progression by suppressing NLRP3 inflammasome pathway.
Mol Cell Endocrinol
January 2025
Department of Ophthalmology, The Third Affiliated Hospital of Soochow University, Changzhou, 213000, China. Electronic address:
Oridonin (Ori) possesses anti-inflammatory properties. However, its potential to treat diabetic retinopathy (DR) remains unclear. This study aimed to investigate the retinal protective function of Ori and the underlying mechanism.
View Article and Find Full Text PDFOridonin Suppresses Mast Cell Degranulation and Alleviates Ovalbumin-Induced Allergic Rhinitis.
Biol Pharm Bull
November 2024
Laboratory of Bioresponse Regulation, Graduate School of Pharmaceutical Sciences, Osaka University.
Incidence of type I allergies, such as hay fever, is continuously increasing in developed countries, including Japan. Type I allergies are triggered by chemical mediators, such as histamine, which are released via immunoglobulin E (IgE)-mediated mast cell degranulation. Therefore, medications inhibiting the synthesis, release, and receptor binding of these mediators are commonly used to manage type I allergy symptoms.
View Article and Find Full Text PDFTerahertz spectroscopy study of oridonin and ponicidin in the anticancer Chinese herbal medicine Rabdosia rubescens.
Front Plant Sci
October 2024
Key Laboratory of Terahertz Optoelectronics, Ministry of Education, Beijing, China.
Rabdosia rubescens, a Chinese herbal medicine with anticancer properties, contains two active ingredients: oridonin and ponicidin. Both compounds exhibit antitumor effects by inducing tumor cell apoptosis and autophagy and inhibiting tumor cell proliferation. To further explore the differences in molecular structure and pharmacological properties between the two substances, this study employs Terahertz Time-Domain Spectroscopy (THz-TDS) to investigate the spectral characteristics of oridonin and ponicidin in the frequency range of 0.
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