Antisense oligonucleotide to alpha2A-adrenoceptors increased the levels of mRNA (reverse polymerase chain reaction) and protein for a key executioner protease of apoptosis caspase-3 (immunoblotting assay) in the cerebral cortex of newborn rats. The relationship between the observed effect and low expression of alpha2-adrenoceptors was confirmed by the possibility of correcting this phenomenon by clonidine (stimulator of alpha2-adrenoceptors).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-007-0088-9 | DOI Listing |
Publication Analysis
Top Keywords
cerebral cortex
8
negative regulation
4
regulation caspase-3
4
caspase-3 expression
4
expression neonatal
4
neonatal cerebral
4
cortex alpha2a-adrenoceptors
4
alpha2a-adrenoceptors antisense
4
antisense oligonucleotide
4
oligonucleotide alpha2a-adrenoceptors
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!