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Overlooked Generation of Reactive Oxidative Species from Water and Dioxygen by Far UV Light.
Environ Sci Technol
December 2024
Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, School of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, P. R. China.
Article Synopsis
- Far UV light at 222 nm is becoming popular for water purification through UV irradiation and advanced oxidation processes (AOPs), mainly removing pollutants via direct photolysis.
- The study highlights the role of reactive oxidative species (ROS) generated from dioxygen and water under UV radiation, with hydroxyl radical (HO) identified as the key player in degrading organic micropollutants.
- The research shows that UV treatment is more effective in removing 18 micropollutants than traditional UV/HO AOP methods, while also being more energy-efficient, proposing a new approach to UV-based water purification.
Gamma-irradiated copper-based metal organic framework nanocomposites for photocatalytic degradation of water pollutants and disinfection of some pathogenic bacteria and fungi.
BMC Microbiol
November 2024
Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El Buhouth St, Dokki, 12622, Giza, Egypt.
Background: Although there are many uses for metal-organic framework (MOF) based nanocomposites, research shows that these materials have received a lot of interest in the field of water treatment, namely in the photodegradation of water contaminants, and disinfection of some pathogenic bacteria and fungi. This is brought on by excessive water pollution, a lack of available water, low-quality drinking water, and the emergence of persistent micro-pollutants in water bodies. Photocatalytic methods may be used to remove most water contaminants, and pathogenic microbes, and MOF is an excellent modifying and supporting material for photocatalytic degradation.
View Article and Find Full Text PDFIdentification and characterization of alkaline hydrolytic degradation products of ivacaftor by UPLC-PDA and UPLC-ESI-QTOF-MS techniques.
Rapid Commun Mass Spectrom
January 2025
University Institute of Pharmaceutical Sciences, UGC Center of Advanced Study, Panjab University, Chandigarh, India.
Rationale: The study of inherent stability characteristics of drugs has been advocated to be important by various regulatory agencies like the ICH, USFDA, and others. The current work was envisaged to investigate the forced degradation profile of the drug ivacaftor under ICH-prescribed stress conditions, identification of its potential degradants, and postulation of the degradation routes for their generation.
Methods: The stress degradation studies were performed on the drug as per the ICH guideline Q1A(R2).
Characterization of disulfide bridges containing cyclic peptide Linaclotide and its degradation products by using LC-HRMS/MS.
J Pharm Biomed Anal
January 2025
Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), An Institute of National Importance, Government of India, Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Opp. Airforce Station, Palaj, Gandhinagar, Gujarat 382355, India.
Article Synopsis
- Linaclotide (LINA) is a medication for treating constipation-related conditions, and researchers studied its stability under various stress conditions to meet international guidelines.
- A new liquid chromatography method was developed to separate and identify LINA's degradation products, using advanced techniques like high-resolution mass spectrometry.
- The study found that LINA degrades under different conditions, leading to the formation of seven degradation products, which were characterized and could help improve drug formulations in the future.
Development and validation of a stability-indicating HPLC method for assay of tonabersat in pharmaceutical formulations.
Methods
November 2024
Buchanan Ocular Therapeutics Unit, Department of Ophthalmology, Aotearoa-New Zealand National Eye Centre, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1142, New Zealand. Electronic address:
A stability-indicating reversed-phase high-performance liquid chromatography (RP-HPLC) method was developed to assay tonabersat and assess its stability in pharmaceutical formulations. Chromatographic separation was achieved using a Kinetex® C18 column (2.6 µm, 150 x 3 mm, 100 Å) at 50 °C, with a 20 µL injection volume.
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