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Effectiveness and safety of traditional Chinese therapies intreating patients with amyotrophic lateral sclerosis: a protocol for systematic review and meta-analysis.
Front Neurol
December 2024
Department of Tuina and Rehabilitation Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China.
Background: Amyotrophic lateral sclerosis (ALS) is a chronic, progressive disease that affects both upper and lower motor neurons. Some physicians have used traditional Chinese therapies (TCT) to treat ALS. However, there has been no systematic review or meta-analysis to evaluate the effectiveness and safety of TCT interventions.
View Article and Find Full Text PDFKinetics of reformation of the S state capable of progressing to the S state after the O release by photosystem II.
Photosynth Res
January 2025
Department of Chemistry, Graduate School of Science and Technology, Proteo-Science Research Center, Ehime University, Bunkyo-cho, Matsuyama, Ehime, 790-8577, Japan.
The active site for water oxidation in photosystem II (PSII) comprises a MnCaO cluster adjacent to a redox-active tyrosine residue (Tyr). During the water-splitting process, the enzyme transitions through five sequential oxidation states (S to S), with O evolution occurring during the STyr· to STyr transition. Chloride also plays a role in this mechanism.
View Article and Find Full Text PDFFast Neuronal Calcium Signals in Brain Slices Loaded With Fluo-4 AM Ester.
Eur J Neurosci
January 2025
Université Grenoble Alpes, CNRS, LIPhy, Grenoble, France.
Staining brain slices with acetoxymethyl ester (AM) Ca dyes is a straightforward procedure to load multiple cells, and Fluo-4 is a commonly used high-affinity indicator due to its very large dynamic range. It has been shown that this dye preferentially stains glial cells, providing slow and large Ca transients, but it is questionable whether and at which temporal resolution it can also report Ca transients from neuronal cells. Here, by electrically stimulating mouse hippocampal slices, we resolved fast neuronal signals corresponding to 1%-3% maximal fluorescence changes.
View Article and Find Full Text PDFInguinal hernia mesh infections: Chronic challenges, atypical pathogens and lessons in sterilisation.
Trop Doct
January 2025
Junior Resident, Department of General Medicine, Silchar Medical College and Hospital, Assam, India.
Chronic mesh infections after inguinal hernia repair present significant clinical challenges due to biofilm-mediated resistance, involvement of multidrug-resistant and atypical pathogens, and gaps in preventive strategies. Our case series of four patients highlights critical research gaps, including the overlooked role of atypical pathogens such as , diagnostic challenges in detecting slow-growing or resistant organisms and perioperative sterilisation lapses, especially inconsistent Glutaraldehyde use during late-day operations. Many patients suffered with persistent sinuses and recurrent hernias months after surgery.
View Article and Find Full Text PDFDesign, optimization, and inference of biphasic decay of infectious virus particles.
J Theor Biol
January 2025
Department of Biology, University of Maryland, College Park, 20742, MD, USA; Institut de Biologie, Ecole Normale Superieure, Paris, 75005, France; School of Biological Sciences, Georgia Institute of Technology, Atlanta, 30332, GA, USA. Electronic address:
Virus population dynamics are driven by counter-balancing forces of production and loss. Whereas viral production arises from complex interactions with susceptible hosts, the loss of infectious virus particles is often approximated as a first-order kinetic process. As such, experimental protocols to measure infectious virus loss are not typically designed to identify non-exponential decay processes.
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