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Biomarkers.
Alzheimers Dement
December 2024
Geroscience Center for Brain Health and Metabolism (GERO), Santiago, Chile.
Background: Chronic exposure to stress, quantified by allostatic load (AL), has been postulated as a cause of structural brain changes in the context of dementia. White matter hyperintensities (WMH), detected in MRI FLAIR, are a common brain abnormality representing small vessel disease or degenerative changes in the brain. Here, we studied differences in tract-specific WMH volume across three risk levels of AL in Chilean subjects with cognitive complaint, to explore links between chronic stress exposure and prodromal steps of dementia.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
University of Kansas Alzheimer's Disease Research Center, Fairway, KS, USA.
Background: Plasma biomarkers show a promising future to improving the quality of diagnosing Alzheimer's Disease (AD). However, blood processing procedures should be considered when measuring plasma biomarkers. Here we investigate brain-derived neurotrophic factor (BDNF) in platelet-rich and platelet-poor plasma.
View Article and Find Full Text PDFBackground: Recent advancements in molecular positron emission tomography (PET) enable precise tracking of tau pathology in Alzheimer's disease (AD). Tau pathology typically begins focally in the medial temporal lobe, rapidly expanding due to amyloid-β (Aβ) influence. This expansion may lead to neurodegeneration along connected pathways to the tau epicenters, resulting in cognitive decline.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Alzheimer's Disease Cooperative Study (ADCS), University of California, San Diego, La Jolla, CA, USA.
Background: The glymphatic system is important for clearing waste and transporting nutrients throughout the brain, but it's still unknown how cerebrospinal fluid (CSF) and cerebral blood flow (CBF) contribute to Alzheimer's Disease (AD). Phase-contrast MRI (PC-MRI) has been shown to reliably measure CSF and CBF at the cerebral aqueduct (CA) and second and third cervical vertebrae (C2-C3) non-invasively. The purpose of this study is to demonstrate CSF and CBF flow dynamics variations by age, sex, and APOE4 status in older adults.
View Article and Find Full Text PDFBackground: Comprehending the role of participatory lifestyle factors influencing the aging process and subsequent cognitive outcomes is imperative for postulating ways to combat cognitive decline. Recent research points to the independent impacts of leisure time activities (LTAs), physical performance (measures of physical fitness) and socialization (relationships and interaction frequency) on healthy cognitive aging, although the relative importance of this triad of factors is poorly delineated.
Method: From baseline data of two studies examining cognitive aging in older, diverse populations- "Study of Healthy Aging in African Americans" and "Kaiser Healthy Aging and Diverse Life Experiences," we scraped subjects' self-reported data and Spanish and English Neuropsychological Assessment Scales (SENAS) measured cognitive performance scores.
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