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Metabolic bioactivation of antidepressants: advance and underlying hepatotoxicity.
Drug Metab Rev
May 2024
Department of Pathology & Immunology, Center for Drug Discovery, Baylor College of Medicine, Houston, TX, USA.
Many drugs that serve as first-line medications for the treatment of depression are associated with severe side effects, including liver injury. Of the 34 antidepressants discussed in this review, four have been withdrawn from the market due to severe hepatotoxicity, and others carry boxed warnings for idiosyncratic liver toxicity. The clinical and economic implications of antidepressant-induced liver injury are substantial, but the underlying mechanisms remain elusive.
View Article and Find Full Text PDFAntidepressant exposure as a source of disinfectant resistance in waterborne bacteria.
J Hazard Mater
June 2023
Department of Environment and Health, Tianjin Institute of Environmental & Operational Medicine, Key Laboratory of Risk Assessment and Control for Environment & Food Safety, Tianjin 300050, China. Electronic address:
The emergence of disinfectant-resistant pathogens in water is a major threat to public health. However, whether human-consumed pharmaceuticals can induce bacterial resistance to disinfectants remains unclear. Herein, Escherichia coli was exposed to 12 antidepressants, and susceptibility of antidepressant-induced chloramphenicol (CHL)-resistant mutants to disinfectants was tested.
View Article and Find Full Text PDF[Preventive and therapeutic effect of bioactive component of licorice on antidepressant-induced liver injury].
Zhongguo Zhong Yao Za Zhi
November 2022
Department of Hepatology, the Fifth Medical Center of PLA General Hospital Beijing 100039, China.
Since exploding rates of modern mental diseases, application of antidepressants has increased. Worryingly, the antidepressant-induced liver injury has gradually become a serious health burden. Furthermore, since most of the knowledge about antidepressant hepatotoxicity are from pharmacovigilance and clinical case reports and lack of observational studies, the underlying mechanisms are poorly understood and there is a lack of efficient treatment strategies.
View Article and Find Full Text PDFAntidepressant-induced serotonin syndrome in older patients: a cross-sectional study.
Psychogeriatrics
July 2022
Unit for Aging Brain and Dementia, Department of Geriatric Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
Background: Widespread prescription of antidepressants and their resulting role in serotonin syndrome (SS) are of great importance for clinical practice in the elderly. This study aims to investigate possible associations of antidepressant drug-induced SS with related variables in these patients.
Methods: A total of 238 older adults using antidepressants were included.
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