AI Article Synopsis
- In 2005, a total of 764 children with hand, foot, and mouth disease were treated at a hospital in Ho Chi Minh City, Vietnam, and specimens were collected to isolate enteroviruses.
- Out of the samples, 411 (53.8%) yielded enteroviruses, with 173 (42.1%) identified as human enterovirus 71 (HEV71) and 214 (52.1%) as coxsackievirus A16.
- Notably, 29.5% of HEV71 cases led to acute neurological complications, and a few were fatal, while HEV71 showed seasonal peaks in prevalence, particularly from October to November, with various subgenogroups
Article Abstract
During 2005, 764 children were brought to a large children's hospital in Ho Chi Minh City, Vietnam, with a diagnosis of hand, foot, and mouth disease. All enrolled children had specimens (vesicle fluid, stool, throat swab) collected for enterovirus isolation by cell culture. An enterovirus was isolated from 411 (53.8%) of the specimens: 173 (42.1%) isolates were identified as human enterovirus 71 (HEV71) and 214 (52.1%) as coxsackievirus A16. Of the identified HEV71 infections, 51 (29.5%) were complicated by acute neurologic disease and 3 (1.7%) were fatal. HEV71 was isolated throughout the year, with a period of higher prevalence in October-November. Phylogenetic analysis of 23 HEV71 isolates showed that during the first half of 2005, viruses belonging to 3 subgenogroups, C1, C4, and a previously undescribed subgenogroup, C5, cocirculated in southern Vietnam. In the second half of the year, viruses belonging to subgenogroup C5 predominated during a period of higher HEV71 activity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375788 | PMC |
| http://dx.doi.org/10.3201/eid1311.070632 | DOI Listing |
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