To date, materials selection in microfluidics has been restricted to conventional micromechanical materials systems such as silicon, glass, and various polymers. Metallic materials offer a number of potential advantages for microfluidic applications, including high fracture toughness, thermal stability, and solvent resistance. However, their exploitation in such applications has been limited. In this work, we present the application of recently developed titanium micromachining and multilayer lamination techniques for the fabrication of dielectrophoresis devices for microfluidic particle manipulation. Two device designs are presented, one with interdigitated planar electrodes defined on the floor of the flow channel, and the other with electrodes embedded within the channel wall. Using these devices, two-frequency particle separation and Z-dimensional flow visualization of the dielectrophoresis phenomena are demonstrated.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10544-007-9159-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Modeling of Electric Field and Dielectrophoretic Force in a Parallel-Plate Cell Separation Device with an Electrode Lid and Analytical Formulation Using Fourier Series.
Sensors (Basel)
December 2024
Department of Applied Physics, National Defense Academy, Hashirimizu 1-10-20, Yokosuka 239-0802, Kanagawa, Japan.
Dielectrophoresis (DEP) cell separation technology is an effective means of separating target cells which are only marginally present in a wide variety of cells. To develop highly efficient cell separation devices, detailed analysis of the nonuniform electric field's intensity distribution within the device is needed, as it affects separation performance. Here we analytically expressed the distributions of the electric field and DEP force in a parallel-plate cell separation DEP device by employing electrostatic analysis through the Fourier series method.
View Article and Find Full Text PDFLight-Emitting Diode Array with Optical Linear Detector Enables High-Throughput Differential Single-Cell Dielectrophoretic Analysis.
Sensors (Basel)
December 2024
Department of Electrical and Computer Engineering, University of Manitoba, Winnipeg, MB R3T 5V6, Canada.
This paper presents a lens-free imaging approach utilizing an array of light sources, capable of measuring the dielectric properties of many particles simultaneously. This method employs coplanar electrodes to induce velocity changes in flowing particles through dielectrophoretic forces, allowing the inference of individual particle properties from differential velocity changes. Both positive and negative forces are detectable.
View Article and Find Full Text PDFLiquid metal electrodes enabled cascaded on-chip dielectrophoretic separation of large-size-range particles.
Lab Chip
December 2024
State Key Laboratory of Precision Measurement Technology and Instrument, Department of Precision Instrument, Tsinghua University, Beijing 100084, P. R. China.
The separation of large-size-range particles of complex biological samples is critical but yet well resolved. As a label-free technique, dielectrophoresis (DEP)-based particle separation faces the challenge of how to configure DEP in an integrated microfluidic device to bring particles of various sizes into the effective DEP force field. Herein, we propose a concept that combines the passive flow fraction mechanism with the accumulative DEP deflection effect in a cascaded manner.
View Article and Find Full Text PDFAnalysis of Cell Dielectrophoretic Properties Using Isomotive Creek-Gap Electrode Device.
Sensors (Basel)
November 2024
Graduate School of Applied Science and Engineering, National Defense Academy, Yokosuka 239-8686, Japan.
Various types of dielectrophoresis (DEP) cell separation devices using AC electric fields have been proposed and developed. However, its capability is still limited by a lack of quantitative characterization of the relationship between frequency and force. In the present study, this limitation was addressed by developing a method capable of fast and accurate quantification of the dielectric properties of biological cells.
View Article and Find Full Text PDFRational microfluidic design for dielectrophoresis-based multitarget separation of blood cells and circulating tumor cells.
Comput Methods Biomech Biomed Engin
December 2024
Department of Radiation Physics, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China.
A rapid, sensitive, and low-damage method for isolating circulating tumor cells (CTCs) is crucial for cancer research. This study, based on dielectrophoresis (DEP) and finite element modeling, investigates multitarget cell separation from blood on microfluidic chips. The effects of electrode shape, dielectric conductivity, and flow rate on cell movement and separation efficiency were analyzed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!