Effect of dimethylsulfoxide on the functions of mesenchymal and hemopoietic precursors.

Bull Exp Biol Med

Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.

Published: April 2007

The effects of dimethylsulfoxide on the state of mesenchymal precursors in vivo were demonstrated. Treatment with dimethylsulfoxide reduced the content of stromal clonogenic elements in the bone marrow and inhibited mobilization of mesenchymal precursors induced by granulocyte colony-stimulating factor. In in vitro system, dimethylsulfoxide inhibited proliferation of fibroblast, erythroid, and granulomonocytic colony-forming units and stimulates maturation of hemopoietic precursors.

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http://dx.doi.org/10.1007/s10517-007-0173-0DOI Listing

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