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Neutralizing Nanobodies against Venoms from Species Captured in North Africa.
Toxins (Basel)
September 2024
Laboratory of Venoms and Theranostic Applications (LR20IPT01), Place Pasteur, BP704, Pasteur Institute of Tunis, Université Tunis el Manar, Tunis 1002, Tunisia.
Article Synopsis
- Snakebite envenoming (SBE) is a major public health problem in tropical areas, especially Africa, where it causes a high number of fatalities and serious health issues due to ineffective antivenom treatments.
- This study focuses on developing nanobodies as a new type of treatment against cobra venoms, investigating toxic venom fractions and their interaction with acetylcholine receptors.
- The research identified two particularly deadly venom fractions, F5 and F6, and demonstrated that combining specific nanobodies could neutralize these venoms effectively in mice, revealing the complex nature of cobra venom's lethal effects.
Development and characterization of nanobody against envenomation by Naja naja oxiana.
Toxicon
October 2024
Venom and Biotherapeutics Molecules Laboratory, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran. Electronic address:
Snakebites are considered a significant health issue. Current antivenoms contain polyclonal antibodies, which vary in their specificity against different venom components. Development and characterization of next generation antivenoms including nanobodies against Naja naja oxiana was the main aim of this study.
View Article and Find Full Text PDFThe Need for Next-Generation Antivenom for Snakebite Envenomation in India.
Toxins (Basel)
August 2023
School of Biotechnology, Amrita Vishwa Vidyapeetham, Kollam 690 525, Kerala, India.
Article Synopsis
- * Current research is exploring new methods like aptamers, camel antivenoms, and small-molecule inhibitors to improve treatment effectiveness against snake venom.
- * This review discusses the challenges faced by Indian polyvalent antivenoms and the potential of these alternative strategies, providing a comprehensive overview of their effectiveness in both lab (in vitro) and real-life (in vivo) scenarios.
Mid-face Massive Loss Reconstruction: Free Latissimus Dorsi Used as Both a Donor and Recipient for Two Subsequent Temporoparietal Flaps.
Plast Reconstr Surg Glob Open
August 2023
From the Plastic Surgery Department, Al Mataria Teaching Hospitals, GOTHI, Cairo, Egypt.
After a camel bite, a man lost much of his mid-face tissues, including right eye, nose, cheeks, upper lip, and palate. A free latissimus dorsi flap was used to simultaneously fill and cover the huge gap and to rebuild the new mouth roof. A few weeks later, it could also offer local hinged flaps working as raw beds to receive a converse scalping flap, and extended temporoparietal flaps were used for reconstruction of the nose and hairy upper lip, respectively.
View Article and Find Full Text PDFMorphological and radiological mapping of dental cusps in relation to spatial constraints on tooth shape of one humped camel (Camelus dromedarius).
Zoological Lett
June 2023
Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Sohag University, Sohag, Egypt.
A significant extent of researches in veterinary study have been focused on dental structure; however, there are scanty ones on the orientation and identification of their cusps. Therefore, the present article aimed to spot a light on arrangement pattern of dental cusps in the camel as a folivorous and graminivorous animal. This study was conducted on eight heads of adult, healthy camel of both sexes, collected from slaughter houses.
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