Acylated derivatives of 4-methyl-1H-tetrahydro-1,5-benzodiazepin-2-one (1) and of 2-methyl-4-phenyl-1H-tetrahydro-1,5-benzodiazepino-2-carboxylic acid ethyl ester (10) were synthesized and preliminarily tested on their central activity. Acylation was carried out with alpha, beta-unsaturated acid chlorides, dicarboxylic acid monoester monochlorides, and dicarboxylic acid dichlorides. Compounds 2, 3, 11 and 12 had analgesic, compounds 4, 11 and 12--anticonvulsant, and compounds 3 and 11--antiaggressive properties.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
acylated derivatives
8
dicarboxylic acid
8
derivatives 15-benzodiazepines
4
15-benzodiazepines acylated
4
derivatives 4-methyl-1h-tetrahydro-15-benzodiazepin-2-one
4
4-methyl-1h-tetrahydro-15-benzodiazepin-2-one 2-methyl-4-phenyl-1h-tetrahydro-15-benzodiazepino-2-carboxylic
4
acid
4
2-methyl-4-phenyl-1h-tetrahydro-15-benzodiazepino-2-carboxylic acid
4
acid ethyl
4
ethyl ester
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!