Purpose: To evaluate the potential of helical tomotherapy in the adjuvant treatment of malignant pleural mesothelioma and compare target homogeneity, conformity and normal tissue dose with step-and-shoot intensity-modulated radiotherapy.
Methods And Materials: Ten patients with malignant pleural mesothelioma who had undergone neoadjuvant chemotherapy with cisplatin and permetrexed followed by extrapleural pneumonectomy (EPP) were treated in our department with 54 Gy to the hemithorax delivered by step-and-shoot IMRT. A planning comparison was performed by creating radiation plans for helical tomotherapy. The different plans were compared by analysing target homogeneity using the homogeneity indices HI(max) and HI(min) and target conformity by using the conformity index CI(95). To assess target coverage and normal tissue sparing TV(90), TV(95) and mean and maximum doses were compared.
Results: Both modalities achieved excellent dose distributions while sparing organs at risk. Target coverage and homogeneity could be increased significantly with helical tomotherapy compared with step-and-shoot IMRT. Mean dose to the contralateral lung could be lowered beyond 5 Gy.
Conclusions: Our planning study showed that helical tomotherapy is an excellent option for the adjuvant intensity-modulated radiotherapy of MPM. It is capable of improving target coverage and homogeneity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.radonc.2007.12.010 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Emerging Radiotherapy Technologies for Head and Neck Squamous Cell Carcinoma: Challenges and Opportunities in the Era of Immunotherapy.
Cancers (Basel)
December 2024
Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC 27599, USA.
Radiotherapy (RT) is an integral component in the multidisciplinary management of patients with head and neck squamous cell carcinoma (HNSCC). Significant advances have been made toward optimizing tumor control and toxicity profiles of RT for HNSCC in the past two decades. The development of intensity modulated radiotherapy (IMRT) and concurrent chemotherapy established the standard of care for most patients with locally advanced HNSCC around the turn of the century.
View Article and Find Full Text PDFEvaluation of Gamma Index Analysis for Detecting Errors in Patient-specific Quality Assurance in Intensity Modulated Radiotherapy.
Health Phys
January 2025
Department of Radiation Oncology, Medicine Faculty of Van Yüzüncü Yıl University, Van, Turkey.
Quality assurance practices performed before treatment are believed to identify various potential errors. In this study, 2-dimensional (2D) dosimetric results were analyzed by making some intentional mistakes in six different treatment plans. In this way, the detectability of errors was investigated.
View Article and Find Full Text PDFIntracranial extension of juvenile nasopharyngeal angiofibroma: patterns of involvement with a proposed algorithm for their management.
J Neurosurg Pediatr
January 2025
1Neurotology Unit, Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow; and.
Objective: The objective of this study was to discuss the characteristics of intracranial extension in patients with juvenile nasopharyngeal angiofibroma (JNA) and propose and an algorithm for its management.
Methods: A retrospective chart review of all patients with JNA who underwent operations between January 2013 and January 2023 was done, and those cases with intracranial extension categorized as stage IIIb, IVa, and IVb according to the Andrews modification of the Fisch staging classification were included in the study. Data were collected about age at presentation, symptoms, radiological findings, routes of intracranial extension, therapeutic management, and follow-up.
Neurocognitive impairment after intensity-modulated radiotherapy in patients with nasopharyngeal cancer: association with radiation dose and retinal vascular characteristics (abridged secondary publication).
Hong Kong Med J
December 2024
Department of Clinical Psychology, Queen Elizabeth Hospital, Hong Kong SAR, China.
Impact of Radiotherapy on Endocrine Function and Gut Microbiota in Cervical Cancer Patients Undergoing Ovarian Transposition.
Int J Womens Health
December 2024
Emergency Room, Shijiazhuang Maternal and Child Health Hospital, Shijiazhuang, People's Republic of China.
Article Synopsis
- The study compares the effects of radiotherapy on ovarian and endocrine functions as well as gut microbiota in cervical cancer patients with and without ovarian transposition.
- The results indicated that patients who underwent ovarian transposition had better ovarian function preservation and improved quality of life scores compared to those who did not.
- Additionally, gut microbiota analysis showed distinct differences in microbial composition between the two groups, indicating the potential impact of ovarian transposition on gut health.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!