AI Article Synopsis
- Research indicates that higher folate intake may lower breast cancer risk, and genetic differences in folate transport and metabolism could play a role.
- A case-control study analyzed 1,009 breast cancer patients and 907 healthy controls, focusing on variations in six folate-related genes.
- The study found no significant links between genetic variations in specific folate-related genes and breast cancer risk, suggesting these genetic factors may not influence breast cancer development.
Article Abstract
Background: An accumulating body of evidence suggests that there is an inverse relationship between the intake of folate (a water-soluble B-vitamin) and the risk of developing breast cancer. Individual variation in the genes involved in the transport of folate, or its metabolism, may affect risk, or may modify the association between folate and breast cancer risk.
Methods: We performed a case-control study to evaluate the association between common polymorphisms in six folate-related genes and the risk of breast cancer in 1,009 breast cancer patients and 907 healthy controls. Study subjects were genotyped for eight single nucleotide polymorphisms (SNPs) in these six genes.
Results: We observed no association between the MTHFR, RFC, MS and MTRR genotypes and the risk of breast cancer.
Conclusion: These data do not support the hypothesis that genetic variation in genes involved in the metabolism of folate are implicated in the etiology of breast cancer.
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| http://dx.doi.org/10.1007/s10549-008-9895-6 | DOI Listing |
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