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Tousled-like kinase loss confers PARP inhibitor resistance in BRCA1-mutated cancers by impeding non-homologous end joining repair.
Mol Med
January 2025
Research Institute, National Cancer Center, Goyang-Si, Gyeonggi-Do, 10408, Republic of Korea.
Background: Double-strand breaks (DSBs) are primarily repaired through non-homologous end joining (NHEJ) and homologous recombination (HR). Given that DSBs are highly cytotoxic, PARP inhibitors (PARPi), a prominent class of anticancer drugs, are designed to target tumors with HR deficiency (HRD), such as those harboring BRCA mutations. However, many tumor cells acquire resistance to PARPi, often by restoring HR in HRD cells through the inactivation of NHEJ.
View Article and Find Full Text PDFAutomated Laser-Assisted Single-Cell Sorting for Cell Functional and RNA Sequencing.
ACS Sens
January 2025
Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, P. R. China.
Accurate and efficient sorting of single target cells is crucial for downstream single-cell analysis, such as RNA sequencing, to uncover cellular heterogeneity and functional characteristics. However, conventional single-cell sorting techniques, such as manual micromanipulation or fluorescence-activated cell sorting, do not match current demands and are limited by low throughput, low sorting efficiency and precision, or limited cell viability. Here, we report an automated, highly efficient single-cell sorter, integrating laser-induced forward transfer (LIFT) with a high-throughput picoliter micropore array.
View Article and Find Full Text PDFHydroxysilylene (HSi-OH) in the gas phase.
J Chem Phys
January 2025
Ideal Vacuum Products, LLC, 5910 Midway Park Blvd. NE, Albuquerque, New Mexico 87109, USA.
The hydroxysilylene (HSiOH) molecule has been spectroscopically identified in the gas phase for the first time. This highly reactive species was produced in a twin electric discharge jet using separate precursor streams of 16O2/18O2 and Si2H6/Si2D6, both diluted in high pressure argon. The strongest and most stable laser induced fluorescence (LIF) signals were obtained by applying an electric discharge to each of the precursor streams and then merging the discharge products just prior to expansion into vacuum.
View Article and Find Full Text PDFA review of uranium (U) elemental detection methods.
Anal Methods
January 2025
National Key Laboratory of Uranium Resources Exploration-Mining and Nuclear Remote Sensing, Beijing, 100029, China.
With the increasing demand for energy, nuclear energy has been developing rapidly. The quantitative detection and qualitative identification of uranium (U) are of great significance for the comprehensive and efficient use of U resources and the control of nuclear and radioactive substances. In this study, the detection of U is divided into liquid sample detection, solid sample detection, gas sample detection, and industrial detection from the perspectives of the sample state and detection environment.
View Article and Find Full Text PDFOnline integration of capillary electrophoresis and dual detector Taylor dispersion analysis a 3D printed instrument.
Analyst
January 2025
Department of Chemistry & Biochemistry, New Mexico State University, Las Cruces, NM, 88003-001, USA.
Hydrodynamic radius () is a descriptive metric of protein structure with the potential to impact drug development, disease diagnosis, and other important research areas of molecular biology. Common instrumental methods for molecular size characterization are disadvantageous due to high sample consumption, measurements made in non-physiological conditions, and/or inaccurate size determinations. Capillary Taylor dispersion analysis (TDA) is a molecular sizing method that utilizes nL sample volumes and achieves absolute size determination without calibration or comparison to standards.
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