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Whole-exome sequencing uncovers the genetic basis of hereditary concomitant exotropia in ten Chinese pedigrees.
BMC Med Genomics
January 2025
The Affiliated Hospital of Yunnan University (The Second People's Hospital of Yunnan Province), Kunming, Yunnan Province, China.
Purpose: To explore possible pathogenic genes for concomitant exotropia using whole-exome sequencing.
Methods: In this study, 47 individuals from 10 concomitant exotropia (including intermittent exotropia and constant exotropia) pedigrees were enrolled. Whole-exome sequencing was used to screen mutational profiles in 25 affected individuals and 10 unaffected individuals.
Assessing Educational Impact of Worldwide Webinar on Management of Myopia Progression in Children.
Int J Environ Res Public Health
December 2024
Division of Pediatric Ophthalmology and Strabismus, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.
Objective: To assess the educational impact of a worldwide webinar approach to myopia progression management in children <8 years and 8-12 years old.
Design: Cross-sectional study.
Methods: A self-administered survey was conducted for attendees of a 3 h worldwide webinar held in two parts on consecutive days on the management of myopia progression in children.
Virtual reality-based Harms tangent screen test for strabismus measurement.
Graefes Arch Clin Exp Ophthalmol
January 2025
Frankfurt Institute for Advanced Studies (FIAS), Frankfurt am Main, Germany.
Purpose: Our study presents a virtual reality-based tangent screen test (VTS) to measure subjective ocular deviations including torsion in nine directions of gaze. The test was compared to the analogous Harms tangent screen test (HTS).
Methods: We used an Oculus Go controller and head-mounted-display with rotation sensors to measure patient's head orientation for the VTS.
Clinical features in patients with acquired intermittent and constant exotropia who underwent surgery.
BMC Ophthalmol
December 2024
School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran.
Background: acquired exotropia mostly manifests as an intermittent form, and very few cases show constant exotrpia. However, the differences in the clinical features of the constant and intermittent exotropia patients has not been clear yet.
Methods: We retrospectively evaluated 6159 patients with exotropia from 2012 to 2022 in Farabi Eye Hospital, Tehran, Iran.
Dorsolateral pontine lesions produce distinct ocular motor abnormalities with anatomical correlations.
Eur J Neurol
January 2025
Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Biomedical Research Institute, Busan, South Korea.
Background And Purpose: The dorsolateral portion of the caudal pons contains the vestibular nucleus (VN) and inferior cerebellar peduncle (ICP) that play important roles in conveying and processing vestibular and ocular motor signals. This study aimed to characterize ocular motor abnormalities along with their anatomical correlations in dorsolateral pons (DLP) lesions.
Methods: We analyzed clinical features, and results of neuro-otological evaluations and neuroimaging of 18 patients with unilateral DLP lesions (17 with DLP infarction and 1 with cavernous malformation) from among 506 patients with pontine infarction in a stroke registry.
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