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The relationship between spontaneous cystic degeneration and pseudocapillarization in sinusoids in the liver of aged Sprague-Dawley rats.
J Toxicol Pathol
January 2025
The Institute of Environmental Toxicology, 4321 Uchimoriya-machi, Joso-shi, Ibaraki 303-0043, Japan.
Cystic degeneration (CD) in the liver is a cyst-like lesion composed of one or more pseudocysts lacking lining cells, occurring spontaneously in rats older than 12 months, with a male predilection. In this study, 32 CDs were identified in 23 out of 104 non-treated, control male Sprague-Dawley rats from two combined chronic toxicity and carcinogenicity studies with agrochemicals. They were examined histologically, histochemically, and immunohistochemically to assess the pathogenesis and pathological significance of CD, focusing on pseudocapillarization in aged rat liver.
View Article and Find Full Text PDFPeliosis hepatis and hepatic fibrosis in a dog infected with multiple species.
J Vet Diagn Invest
January 2025
Intracellular Pathogens Research Laboratory, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.
A 13-y-old, spayed female dog had regenerative anemia, lymphopenia, hypoalbuminemia, and elevated hepatic biochemical parameters. Liver biopsy revealed hepatic peliosis (hepatic sinusoidal angiectasis), frequently associated with perisinusoidal fibrosis. The dog was seroreactive to antigens by indirect fluorescent antibody assays, and quantitative PCR from blood identified subsp.
View Article and Find Full Text PDFFoxa deficiency restricts hepatitis B virus biosynthesis through epigenic silencing.
J Virol
November 2024
Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.
Unlabelled: In the hepatis B virus (HBV) transgenic mouse model of chronic infection, the forkhead box protein A/hepatocyte nuclear factor 3 (Foxa/HNF3) family of pioneer transcription factors are required to support postnatal viral demethylation and subsequent HBV transcription and replication. Liver-specific Foxa-deficient mice with hepatic expression of only Foxa3 do not support HBV replication but display biliary epithelial hyperplasia with bridging fibrosis. However, liver-specific Foxa-deficient mice with hepatic expression of only Foxa1 or Foxa2 also successfully restrict viral transcription and replication but display only minimal alterations in liver physiology.
View Article and Find Full Text PDFUnusual case of liver cirrhosis presenting as a mass compressing the inferior vena cava: A case report.
Radiol Case Rep
December 2024
Department of Internal Medicine, Las Palmas Del Sol Medical Center, El Paso, TX, USA.
Article Synopsis
- Liver cirrhosis is a major health issue globally, causing around 2 million deaths annually, with various causes including viral infections, toxins, autoimmune diseases, and metabolic disorders.
- Common symptoms of cirrhosis include jaundice, nausea, vomiting, and abnormal liver enzymes, with imaging often showing liver fibrosis.
- A case study is presented of a 38-year-old woman with cirrhosis characterized by a mass compressing the inferior vena cava, which is an unusual manifestation compared to typical fibrotic changes.
Morio Kasai Corrects the Uncorrectable: Hepatic Portoenterostomy for Biliary Atresia.
J Pediatr Surg
December 2024
Mercer University School of Medicine, Columbus Campus, Columbus, GA 31901, USA. Electronic address:
One of the fundamental innovations of pediatric surgery is hepatic portoenterostomy for biliary atresia, widely known as the Kasai procedure for its originator, Morio Kasai (1922-2008), of Sendai, Japan. It was the first effective operation for the "uncorrectable" form of biliary atresia, where death within months from biliary cirrhosis was certain. His radical premise was that microscopic ductules present in the fibrous tissue of the porta hepatis, when transected, drained enough bile to relieve cholestatic jaundice.
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