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Involvement of ATF6 in Octreotide-Induced Endothelial Barrier Enhancement.
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November 2024
School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe, Monroe, LA 71201, USA.
: Endothelial hyperpermeability is the hallmark of severe disease, including sepsis and acute respiratory syndrome (ARDS). The development of medical countermeasures to treat the corresponding illness is of utmost importance. Synthetic somatostatin analogs (SSA) are FDA-approved drugs prescribed in patients with neuroendocrine tumors, and they act via growth hormone (GH) suppression.
View Article and Find Full Text PDFDelayed atorvastatin delivery promotes recovery after experimental spinal cord injury.
Neurotherapeutics
January 2025
Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN 55905, USA; Department of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, MN, USA; Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address:
Spinal cord injury (SCI) significantly alters gene expression, potentially impeding functional recovery. This study investigated the effects of atorvastatin, a widely prescribed cholesterol-lowering drug, on gene expression and functional recovery in a chronic murine SCI model. Female C57BL/6J mice underwent moderate 0.
View Article and Find Full Text PDFEvaluation of a Miniature, Injectable, Wireless Stimulator to Treat Obstructive Sleep Apnea.
Neuromodulation
December 2024
StimAire Corporation, Tucson, AZ, USA.
Introduction: Moderate-to-severe obstructive sleep apnea (OSA) affects a large segment of the US population and is characterized by repetitive and reversible obstruction of the upper airway during sleep. Untreated OSA is associated with increased incidence of heart attack, stroke, and motor vehicle accidents due to sleepiness. Continuous positive airway pressure is often prescribed, but most patients with OSA are nonadherent.
View Article and Find Full Text PDFEarly adolescent second-generation antipsychotic exposure produces long-term, post-treatment increases in body weight and metabolism-associated gene expression.
Pharmacol Biochem Behav
December 2024
Pennington Biomedical Research Center, Baton Rouge, LA 70808, United States of America.
The use of second-generation antipsychotic (SGA) medications in pediatric patients raises concerns about potential long-term adverse outcomes. The current study evaluated the long-term effects of treatment with risperidone or olanzapine on body weight, caloric intake, serum insulin, blood glucose, and metabolism-associated gene expression in C57Bl/6J female mice. Compared to mice treated with vehicle, female mice treated with risperidone or olanzapine gained weight at higher rates during treatment and maintained higher body weights for months following treatment cessation.
View Article and Find Full Text PDFA Three-Stage Cellular Automata Model of Complex Large Roundabout Traffic Flow, with a Flow-Efficiency- and Safety-Enhancing Strategy.
Sensors (Basel)
November 2024
Yangtze Delta Region Academy of Beijing Institute of Technology, Jiaxing 314019, China.
Intelligent transportation systems (ITSs) present new opportunities for enhanced traffic management by leveraging advanced driving behavior sensors and real-time information exchange via vehicle-based and cloud-vehicle communication technologies. Specifically, onboard sensors can effectively detect whether human-driven vehicles are adhering to traffic management directives. However, the formulation and validation of effective strategies for vehicle implementation rely on accurate driving behavior models and reliable model-based testing; in this paper, we focus on large roundabouts as the research scenario.
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