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Predicting transcriptional changes induced by molecules with MiTCP.
Brief Bioinform
November 2024
Department of Automation, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai 200240, China.
Studying the changes in cellular transcriptional profiles induced by small molecules can significantly advance our understanding of cellular state alterations and response mechanisms under chemical perturbations, which plays a crucial role in drug discovery and screening processes. Considering that experimental measurements need substantial time and cost, we developed a deep learning-based method called Molecule-induced Transcriptional Change Predictor (MiTCP) to predict changes in transcriptional profiles (CTPs) of 978 landmark genes induced by molecules. MiTCP utilizes graph neural network-based approaches to simultaneously model molecular structure representation and gene co-expression relationships, and integrates them for CTP prediction.
View Article and Find Full Text PDFPredicting surgical site infections after open reduction and internal fixation for ankle fractures.
Arch Orthop Trauma Surg
January 2025
Trauma Unit, Department of Surgery, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands.
Introduction: Surgical site infections (SSI) are one of the more severe complications following ankle surgery. It is associated with worse outcomes and re-admissions. Therefore, identification of risk factors is essential.
View Article and Find Full Text PDFEnhanced Mechanical Properties in Bulk Nanograined Ni with High-Density Fivefold Twins.
Small
January 2025
Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, 110016, China.
Fivefold twins are extensively present in nanoparticles and nanowires, enhancing their performance in physical, chemical, and mechanical properties. However, a deep insight into the correlation between mechanical properties and fivefold twins in bulk nanograined materials is lacking due to synthesis difficulties. Here, a bulk fivefold-twinned nanograined Ni is synthesized via electrodeposition.
View Article and Find Full Text PDFObjectives: The pairing of immunotherapy and radiotherapy in the treatment of locally advanced nonsmall cell lung cancer (NSCLC) has shown promise. By combining radiotherapy with immunotherapy, the synergistic effects of these modalities not only bolster antitumor efficacy but also exacerbate lung injury. Consequently, developing a model capable of accurately predicting radiotherapy- and immunotherapy-related pneumonitis in lung cancer patients is a pressing need.
View Article and Find Full Text PDF'Piloting a framework for analysing the public contributions to R&D: new antibiotics in focus'.
J Pharm Policy Pract
January 2025
Austrian Institute for Health Technology Assessment (AIHTA), Vienna, Austria.
Background: Within the context of increasing transparency around public contributions, a framework for reporting and analysing public contributions to research and development (R&D) was previously developed and is piloted here using the example of antibiotics. The aim of this work is to check whether the category system is feasible, to revise and adjust the granularity of the category system where necessary, and to expand the range of sources for detailed analyses.
Methods: All antimicrobial medicinal products in development, discontinued and approved in the last 10 years were identified in the literature.
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