Bovine rhinovirus 2 (BRV2), a causative agent of respiratory disease in cattle, is tentatively assigned to the genus Rhinovirus in the family Picornaviridae. A nearly full-length cDNA of the BRV2 genome was cloned and the nucleotide sequence determined. BRV2 possesses a putative leader proteinase, a small 2A protein and a poly(C) tract, which are characteristic of aphthoviruses. Alignment of BRV-2 and FMDV polyproteins showed that 41% of amino acids were identical within the P1 region. Furthermore, 2A, 2C, 3B(3), 3C and 3D proteins are as much as 67%, 52%, 52%, 50%, and 64% identical, respectively. BRV2 leader protein is rapidly released from the viral polyprotein and cleaves eIF4G at a rate similar to FMDV leader proteinase, suggesting a functional relationship between the leader protein in these viruses. The results suggest that BRV2 is closely related to FMDV and should therefore be considered as a new species within the genus Aphthovirus.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.virol.2007.12.019 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
In Vitro Potential Virucidal Effect Evaluation of Xibornol on Human Adenovirus Type 5, Human Rhinovirus Type 13, Human Coronavirus 229E, Human Parainfluenza Virus Type 1, and Human Respiratory Syncytial Virus.
Adv Exp Med Biol
June 2023
Laboratory of Hygiene and Environmental Virology, Department of Biology, University of Pisa, Pisa, Italy.
The availability of virucidal compounds to reduce the impact of respiratory viruses is a relevant topic for public health, especially during the recent coronavirus disease (COVID-19) pandemic. Antimicrobial properties of Xibornol are known since the 1970s, but its activity on viruses is currently little explored. In this study, Xibornol activity at a fixed concentration of 0.
View Article and Find Full Text PDFEfficacy of oleandrin and PBI-05204 against bovine viruses of importance to commercial cattle health.
Antivir Chem Chemother
May 2022
Departments of Thoracic, Head and Neck Medical Oncology and Veterinary Sciences, 4002The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Background: Bovine viral diarrhea virus (BVDV), bovine respiratory syncytial virus (BRSV). and bovine coronavirus (BCV) threaten the productivity of cattle worldwide. Development of therapeutics that can control the spread of these viruses is an unmet need.
View Article and Find Full Text PDFThe antiviral activity of iota-, kappa-, and lambda-carrageenan against COVID-19: A critical review.
Clin Epidemiol Glob Health
June 2021
Research Division for Natural Product Technology (BPTBA), Indonesian Institute of Sciences (LIPI), Jalan Jogja-Wonosari 31.5, Daerah Istimewa Yogyakarta, 55861, Indonesia.
Objective: There is no specific antiviral treatment available for coronavirus disease 2019 (COVID-19). Among the possible natural constituents is carrageenan, a polymer derived from marine algae that possesses a variety of antiviral properties. The purpose of this review was to summarize the evidence supporting carrageenan subtypes' antiviral activity against the emerging severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19.
View Article and Find Full Text PDFFuture antiviral polymers by plasma processing.
Prog Polym Sci
July 2021
School of Chemistry and Physics and QUT Centre for Materials Science, Queensland University of Technology (QUT), 4000 Brisbane, Australia.
Coronavirus disease 2019 (COVID-19) is largely threatening global public health, social stability, and economy. Efforts of the scientific community are turning to this global crisis and should present future preventative measures. With recent trends in polymer science that use plasma to activate and enhance the functionalities of polymer surfaces by surface etching, surface grafting, coating and activation combined with recent advances in understanding polymer-virus interactions at the nanoscale, it is promising to employ advanced plasma processing for smart antiviral applications.
View Article and Find Full Text PDFLactoferrin affects rhinovirus B-14 entry into H1-HeLa cells.
Arch Virol
April 2021
Departamento de Bioquímica, Instituto Biomédico, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Lactoferrin is part of the innate immune system, with antiviral activity against numerous DNA and RNA viruses. Rhinoviruses, the leading cause of the common cold, are associated with exacerbation of respiratory illnesses such as asthma. Here, we explored the effect of bovine lactoferrin (BLf) on RV-B14 infectivity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!