The role of the invariant residue B26-tyrosine in determining the structural and biological properties of insulin has been extensively investigated by the use of semisynthetic des-(B27-B30)-insulins with modifications of position B26. Apart from the conventional trypsin-catalyzed peptide bond formation between the C-terminal amino acid ArgB22 of des-(B23-B30)-insulin and synthetic tetrapeptides we elaborated a new approach using des-(B26-B30)-insulin as substrate in alpha-chymotrypsin-mediated syntheses. Results obtained from bioassays and CD-spectroscopy underline the importance of position B26 to the association of the native molecule and to the modulation of structural and hormonal properties of shortened insulins.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Determinants of oral health status: an ecological study in Iran.
BMC Oral Health
November 2023
Department of Community Oral Health, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Objectives: The aim of this ecological study was to assess the association between behavioral, social position, circumstance factors, and caries experience in 35- to 44-year-old adults in Iran at a provincial level.
Materials And Methods: The data from the 2011 Iranian Oral Health Survey were obtained from all 31 provinces across Iran on the population level. Oral health status was measured as the number of decayed, missing (MT), and filled (FT) teeth and the percentage of the population who were edentulous.
Evaluation of occlusal bite force distribution by T-Scan in orthodontic patients with different occlusal characteristics: a cross sectional-observational study.
BMC Oral Health
November 2023
Orthodontic Division, Preventive Dentistry Department, Jouf University, Sakaka, Aljouf, Saudi Arabia.
Background: The aim of orthodontic treatment, apart from esthetic and functional corrections, is uniform force distribution. Hence Occlusal analysis using a T scan gives scope for a precisely targeted treatment plan. The T-scan evaluation of occlusal force, time, and location of contacts from initial occlusal contact to maximum intercuspation enables the orthodontist to sequentially balance the occlusal forces on the right and left sides through specific treatment plan options.
View Article and Find Full Text PDFPhenotypic and genomic characterization of gen. nov., sp. nov., a cultivated representative of the archaeal class .
Front Microbiol
August 2023
Winogradsky Institute of Microbiology, FRC Biotechnology, Russian Academy of Sciences, Moscow, Russia.
are widespread in various anoxic ecosystems and are considered one of the most abundant microbial groups on the earth. There are only a few reports of laboratory cultivation of , and none of the representatives of this class has been isolated in pure culture. Here, we report a sustainable cultivation of the archaeon (strain M17C) enriched from anaerobic sediment of a coastal lake.
View Article and Find Full Text PDFRegioselective B2-6 penta-iodination of the [CBH] monocarborane cluster by palladium catalysis.
Dalton Trans
August 2023
Department of Chemistry, Zhejiang University, 866 Yuhangtang Road, 310058 Hangzhou, China.
Penta-iodination of the B2-6 positions of the {CB} monocarborane cluster is reported. Products of the structure [2,3,4,5,6-I-CBH-12-X] (X = H, Me, Et, Ph, Br, I) were obtained and fully characterized. X-ray crystal structures of three new compounds confirm this particular substitution pattern.
View Article and Find Full Text PDFImpaired cerebral oxygenation in heart failure patients at rest and during head-up tilt testing.
ESC Heart Fail
February 2021
Department of Clinical Sciences, Lund University, Malmö, 20213, Sweden.
Aims: Heart failure (HF) confers potentially negative effects on the brain and autonomic nervous system. The measurement cerebral tissue oxygen saturation (SctO ) may aid in understanding such effects. We aimed to investigate if compensated HF affects SctO at rest and during orthostatic challenge.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!