The synthesis of (-)-Indolizidine 167B has been achieved from optically active (R)-3-(pyrrol-1-yl)hex-1-ene. The key step is a highly regioselective hydroformylation reaction and a one-pot intramolecular cyclization providing a general approach to the indolizine nucleus.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241606 | PMC |
| http://dx.doi.org/10.1186/1860-5397-4-2 | DOI Listing |
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