AI Article Synopsis
- A rare case of dedifferentiated chondrosarcoma with a leiomyosarcomatous component in a 63-year-old man who had an osteochondroma near his knee is discussed.
- The patient experienced swelling and pain, leading to a biopsy that revealed dedifferentiated cancer, along with multiple lung metastases.
- Despite undergoing amputation and chemotherapy, he passed away two years later due to lung metastasis, highlighting the aggressive nature of this rare cancer variant.
Article Abstract
Background: A rare variant of dedifferentiated chondrosarcoma with leiomyosarcomatous component in a 63-year-old male is reported.
Case Report: He had a life-long osteochondroma adjacent to the left knee and recently developed swollen and pain. We initially suspected an intermediate grade chondrosarcoma arising in a solitary osteochondroma, but a biopsy specimen revealed a dedifferentiated component that histologically was classified as leiomyosarcoma. Multiple lung metastases were also present. The patient underwent amputation above knee and lung operation following adjuvant chemotherapy, but he died because of pulmonary metastasis 2 years after first admission.
Discussion: The differentiated component usually shows the histological features of osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma. Among the rare dedifferentiation with leiomyosarcomatous component, case arising in a solitary osteochondroma is not reported yet.
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| http://dx.doi.org/10.1007/s00402-008-0567-0 | DOI Listing |
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