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The time-multiplexing super-resolution concept requires post-processing for extracting the super-resolved image. Moreover, to perform the post-processing image restoration, one needs to know the exact high-resolution encoding pattern. Both of these limiting conditions are overcome by the method and experiment reported in this letter.
View Article and Find Full Text PDFLinear digital filters are at the core of image reconstruction and processing for many coherent optical imaging techniques, such as digital holography (DH) or optical coherence tomography (OCT). They can also be efficiently implemented using fast Fourier transform (FFT) with appropriate transfer/filter functions that operate in the frequency domain. However, even with optimal filter design, they suffer from side effects such as sidelobe generation or resolution limitations, e.
View Article and Find Full Text PDFSmall CAG Repeat RNA Forms a Duplex Structure with Sticky Ends That Promote RNA Condensation.
J Am Chem Soc
January 2025
Hangzhou Institute of Medicine, Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China.
Biomolecular condensation lays the foundation of forming biologically important membraneless organelles, but abnormal condensation processes are often associated with human diseases. Ribonucleic acid (RNA) plays a critical role in the formation of biomolecular condensates by mediating the phase transition through its interactions with proteins and other RNAs. However, the physicochemical principles governing RNA phase transitions, especially for short RNAs, remain inadequately understood.
View Article and Find Full Text PDFRBBP6 anchors pre-mRNA 3' end processing to nuclear speckles for efficient gene expression.
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Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA. Electronic address:
Pre-mRNA 3' processing is an integral step in mRNA biogenesis. However, where this process occurs in the nucleus remains unknown. Here, we demonstrate that nuclear speckles (NSs), membraneless organelles enriched with splicing factors, are major sites for pre-mRNA 3' processing in human cells.
View Article and Find Full Text PDFLow-Grade Endometrial Stromal Sarcoma: A Case Report of a Rare Uterine Malignancy Mimicking Degenerative Uterine Leiomyoma in a Nulliparous Woman.
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Department of Radiology, Jeonbuk National University Medical School and Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju 54907, Jeonbuk, Republic of Korea.
Low-grade endometrial stromal sarcoma (LGESS) is a rare uterine malignancy that causes non-specific symptoms which presents more typically in younger women compared to other uterine sarcomas. Preoperative diagnosis of myometrial LGESS is challenging, as it is frequently mistaken for a benign uterine mass, such as a degenerating leiomyoma. Despite its rarity, the imaging findings of LGESS are highly variable, complicating the diagnostic process.
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