An 82-year-old female with unresectable colon cancer accompanied by multiple lung metastasis was treated with S-1. Our course consisted of S-1(80 mg/body)from day 1 to 5 followed by 2 days rest. After 14 courses, multiple lung metastasis decreased in size. After 20 courses, the multiple lung metastasis disappeared and local recurrence of colon cancer decreased. Weekly S-1 leads to a partial response. Our chemotherapy showed simple and good compliance for a patient over 80 years old.
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